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Study of the Benefit of Exercise and Aminoacid Supplements in Cirrhotic Patients

2014-08-27 03:16:14 | BioPortfolio

Summary

This is a pilot study including 20 cirrhotic patients that will be randomized to receive during 3 months leucine vs leucine plus a programme of physical exercise specially designed for cirrhotic patients. The hypothesis is that physical exercise in cirrhotic patients could increase muscle mass (and therefore glutamine synthetase activity leading to a higher blood ammonium clearance) and quality of life. Safety of physical exercise in cirrhotic patients will be strictly assessed.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Cirrhosis

Intervention

Exercise, Leucine supplements

Location

Hospital de la Santa Creu i Sant Pau
Barcelona
Spain
08041

Status

Recruiting

Source

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:14-0400

Clinical Trials [1993 Associated Clinical Trials listed on BioPortfolio]

Study to Assess the Effect of a Leucine Supplement Along With Resistance Exercise on Functionality in Frail Elders

The purpose of this study is to determine whether a nutritional supplement with an amino acid called leucine along with resistance exercise are effective in the improvement of functionalit...

Dietary Supplements and Exercise in Aging Adults

The purpose of this study is to determine the effects of food supplements and strength training on appetite, the amount of energy used, and body composition.

Whey vs Casein to Combat Post-inflammatory Protein and Muscle Waste in Acute Disease

This study compares three different protein supplements (casein, whey and leucine-enriched whey) and their effect on post-inflammatory muscle waste in a model of acute disease. Each test p...

Requirement for Leucine in Adults Over 65 Years

This study aims to determine the requirement for leucine, an essential amino acid, in adults over the age of 65 years. It is known that protein and amino acid metabolism may be altered wit...

A Pilot, Phase I/II Study of the Amino Acid Leucine in the Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia

This study will determine the safety and possibility of giving the amino acid, leucine, in patients with Diamond Blackfan anemia(DBA)who are on dependent on red blood cell transfusions. ...

PubMed Articles [2890 Associated PubMed Articles listed on BioPortfolio]

Effects of dietary protein contents and habitual endurance exercise on supplemental leucine oxidation in mice.

The effects of dietary protein contents and regular exercise on the oxidation of supplemented leucine were examined. In the short-term study, male BALB/cCrSlc mice were fed diets containing 0, 10, 20,...

The effect of the branched-chain amino acids on the in-vitro activity of bovine intestinal alkaline phosphatase.

Branched-chain amino acids (BCAA) are used as nutritional support for patients with a range of conditions including liver cirrhosis and in-born errors of amino acid metabolism, and are commonly used "...

Changes in serum levels of leucine-rich α2-glycoprotein predict prognosis in primary biliary cholangitis.

A noninvasive biomarker for patients with primary biliary cholangitis (PBC) is needed. The association between leucine-rich alpha 2 glycoprotein (LRG) and PBC has not been investigated. We aimed to as...

Leucine Metabolites Do Not Enhance Training-induced Performance or Muscle Thickness.

Leucine metabolites, α-hydroxyisocaproic acid (α-HICA) and β-hydroxy-β-methylbutyrate (calcium, HMB-Ca and free acid, HMB-FA), have been proposed to augment resistance training-induced changes in ...

Effects of moderate exercise and a multiple vitamin and mineral complex on the arterial wall.

Aerobic exercise has favorable effects on vascular structure and function. Its beneficial role may be due to a decrease in oxidative stress. The association of vitamin and mineral supplements to exerc...

Medical and Biotech [MESH] Definitions

The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.

Controlled physical activity, more strenuous than at rest, which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used. The intensity of exercise is often graded, using criteria such as rate of work done, oxygen consumption, and heart rate.

A LEUCINE and DNA-binding protein that is found primarily in BACTERIA and ARCHAEA. It regulates GENETIC TRANSCRIPTION involved in METABOLISM of AMINO ACIDS in response to the increased concentration of LEUCINE.

An octameric enzyme belonging to the superfamily of amino acid dehydrogenases. Leucine dehydrogenase catalyzes the reversible oxidative deamination of L-LEUCINE, to 4-methyl-2-oxopentanoate (2-ketoisocaproate) and AMMONIA, with the corresponding reduction of the cofactor NAD+.

Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.

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