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DNA Analysis in Predicting Response to Antibody Therapy in Patients With Follicular Lymphoma Treated on Clinical Trials CALGB-50402 or CALGB-50701

2014-08-27 03:16:21 | BioPortfolio

Summary

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how well patients will respond to treatment.

PURPOSE: This research study is looking at DNA in blood samples to see how well it predicts response to antibody therapy in patients with follicular lymphoma treated on clinical trials CALGB-50402 or CALGB-50701.

Description

OBJECTIVES:

Primary

- To test the hypothesis that killer immunoglobulin-like receptor (KIR) and HLA genotypes predict 12-month overall response (complete response, partial response, and unconfirmed complete response) in patients with follicular lymphoma treated with rituximab-containing monoclonal antibody combinations on CALGB-50402 or CALGB-50701.

Secondary

- To test the hypothesis that KIR and HLA genotypes are associated with survival outcomes (progression-free and overall survival) in these patients.

OUTLINE: This is a multicenter study.

Genomic DNA is extracted from previously collected whole blood samples for killer immunoglobulin-like receptor (KIR) and HLA genotyping and polymorphism analysis.

Study Design

N/A

Conditions

Lymphoma

Intervention

rituximab, gene expression analysis, polymorphism analysis, laboratory biomarker analysis

Status

Active, not recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:21-0400

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Medical and Biotech [MESH] Definitions

MOLECULAR BIOLOGY techniques used in the diagnosis of disease. Included are such techniques as IN SITU HYBRIDIZATION of chromosomes for CYTOGENETIC ANALYSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS of gene expression patterns in disease states; identification of pathogenic organisms by analysis of species specific DNA sequences; and detection of mutations with POLYMERASE CHAIN REACTION.

Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.

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A method of chemical analysis based on the detection of characteristic radionuclides following a nuclear bombardment. It is also known as radioactivity analysis. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

RESTRICTION FRAGMENT LENGTH POLYMORPHISM analysis of rRNA genes that is used for differentiating between species or strains.

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