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Effects of Nebivolol on Exercise Tolerance and Left Ventricular Systolic and Diastolic Function

2014-08-27 03:16:21 | BioPortfolio

Summary

The goal of this pilot study is to effectively treat hypertension in subjects with either known or newly diagnosed hypertension and concurrent evidence of diastolic dysfunction. In patients with predominantly diastolic heart failure it is hypothesized that by using more robust echocardiographic measures of diastolic dysfunction, significant changes will be detected. Furthermore, due to the unique properties of nebivolol it is also hypothesized that there will be improvements in LV function manifesting as increased exercise capacity as well as LVH regression as measured by echocardiography. The investigators hope to reproduce the findings shown in a prior study that showed increased stroke volume and preservation of CO in subjects receiving nebivolol.

Study Design

Allocation: Non-Randomized, Masking: Open Label, Primary Purpose: Treatment

Conditions

Hypertension

Intervention

Nebivolol

Location

St. John's Mercy Cardiovascular Research
St. Louis
Missouri
United States
63141

Status

Recruiting

Source

St. John's Health System, Missouri

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:21-0400

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PubMed Articles [2011 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

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Familial or idiopathic hypertension in the PULMONARY CIRCULATION which is not secondary to other disease.

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