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Purpose: Phase IV switching study to Elazop to evaluate efficacy and safety in patients with open angle glaucoma
This is a multi-center, open-labeled, exploratory, interventional, prospective study. The study will not be conducted concurrently at all clinical sites. The 12 weeks study consists of 4 different study visits to the clinical site (Screening, Day 1, Week 4 and Week 12). During Visit 1 (Screening Visit), patients will be assessed for their eligibility to participate in the study; an intraocular pressure (IOP) measurement will be taken to determine if the patient's IOP is within the required range for this study (between 16 to 35 mmHg, both inclusive). The patients who meet the eligible criteria will be required to stop taking their previous ocular hypertensive medications for 4 weeks washout period following the screening visit. At the Day 1 Visit (baseline visit), eligibility of the patients will be reconfirmed (i.e., IOP range must be between 16 to 35 mmHg, both inclusive). At Day 1 Visit, eligible patients will the receive study medication with proper dosing instructions (to be administered twice a day) for up to 12 weeks. Patients will be required to return to the clinical site at Visit 3 (Week 4) for IOP measurements and safety assessments. At the Visit 4 (Week 12; exit visit), the patient's IOP will be measured and then patients will be exited from the study after all exit procedures have been completed.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Open Angle Glaucoma
Seoul National University Bundang Hospital
Korea, Republic of
Not yet recruiting
Published on BioPortfolio: 2014-08-27T03:16:26-0400
The purpose of this study is to evaluate the intraocular pressure (IOP) lowering effect of two iStent devices in eyes of subjects with primary open-angle glaucoma
The purpose of the study is to determine whether a glaucoma therapy is safe and effective in treating patients with open-angle glaucoma or ocular hypertension
The Erlangen Glaucoma Registry is a clinical registry for cross sectional and longitudinal observation of patients with open angle glaucoma (OAG) or glaucoma suspect, founded in 1991. The ...
To determine the safety and IOP-lowering ability of a test compound in patients with open-angle glaucoma or ocular hypertension.
The purpose of this study is to determine the safety and IOP-lowering ability of a glaucoma therapy in patients with open-angle glaucoma or ocular hypertension
To compare the anterior and posterior choroid thickness (ACT and PCT, respectively) in primary open-angle glaucoma (POAG), primary angle-closure disease (PACD), and healthy control subjects.
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To determine the level of adherence to the American Academy of Ophthalmology (AAO) preferred practice pattern (PPP) guidelines for quality primary open angle glaucoma (POAG) and POAG suspect (POAGS) c...
To determine whether mitochondrial DNA haplogroups or rare variants associate with primary open-angle glaucoma in subjects of European descent.
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A cloprostenol derivative that is used as an ANTIHYPERTENSIVE AGENT in the treatment of OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION.
A cloprostenol-derived amide that is used as an ANTIHYPERTENSIVE AGENT in the treatment of OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION.
A quinoxaline derivative and ADRENERGIC ALHPA-2 RECEPTOR AGONIST that is used to manage INTRAOCULAR PRESSURE associated with OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION.
Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.
Congenital open-angle glaucoma that results from dysgenesis of the angle structures accompanied by increased intraocular pressure and enlargement of the eye. Treatment is both medical and surgical.
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...