ARQ 197 for Subjects With Relapsed or Refractory Germ Cell Tumors

2014-08-27 03:16:27 | BioPortfolio


This is a multicenter, single-arm study for safety and efficacy.

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Non-CNS Germ Cell Tumors (Seminomas and Nonseminomas)


ARQ 197


Memorial Sloan Kettering
United States




Daiichi Sankyo Inc.

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:16:27-0400

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PubMed Articles [17927 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.

A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)

The process of germ cell development in the female from the primordial germ cells through OOGONIA to the mature haploid ova (OVUM).

Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.

The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.

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