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Effect of Seminal Fluid on the Colon Wall; Implications for HIV Transmission

2014-08-27 03:16:28 | BioPortfolio

Summary

This research is being done to learn how seminal fluid affects the lining of the colon, and whether this might make it easier for HIV to get into the body and cause infection.

Description

Design of effective rectal microbicides to prevent HIV infection requires an understanding of rectal HIV transmission and the location within the lower gastrointestinal (GI) tract (luminal and mucosal) of HIV (cell-free and cell-associated) following exposure to infected seminal fluid. These basic details of HIV transmission have yet to be determined in human subjects, yet they are essential to select microbicide candidates if they are to be rationally designed to achieve effective concentrations at sites of HIV transmission. Rational development of a rectal microbicide also requires an understanding of those factors that may contribute to colonic mucosal injury - potential confounders of microbicidal effect. Such factors include exposure to seminal fluid which has been shown in animal and in vitro studies to cause histologic and permeability changes that might facilitate HIV transmission.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science

Conditions

Human Immunodeficiency Virus (HIV)

Intervention

Autologous seminal fluid with Tc-99m/In-111 radiolabels, Autologous lymphocytes labeled with In-111 in normosol vehicle with TC-99m DTPA incorporated

Location

Johns Hopkins University Drug Development Unit
Baltimore
Maryland
United States
21287

Status

Completed

Source

Johns Hopkins University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:28-0400

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Glands situated on each side of the prostate that secrete a fluid component of the seminal fluid into the urethra.

Transplantation from another site in or on the body of the individual receiving it.

Reinfusion of blood or blood products derived from the patient's own circulation. (Dorland, 27th ed)

Proteins found in SEMEN. Major seminal plasma proteins are secretory proteins from the male sex accessory glands, such as the SEMINAL VESICLES and the PROSTATE. They include the seminal vesicle-specific antigen, an ejaculate clotting protein; and the PROSTATE-SPECIFIC ANTIGEN, a protease and an esterase.

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