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Gabapentin in the Prevention of Nausea and Vomiting Induced by Chemotherapy

2014-08-27 03:16:32 | BioPortfolio

Summary

Gabapentin is an antiepileptic drug. Its antiemetic effect is demonstrated after laparoscopic surgery, but it is not yet known whether gabapentin is effective in preventing chemotherapy induced emesis.

The purpose of this study is to determine whether the addition of gabapentin to dexamethasone plus ondansetron increase the control of chemotherapy-induced nausea and vomiting.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Vomiting

Intervention

Placebo, Gabapentin

Location

Faculdade de Medicina do ABC
Santo André
São Paulo
Brazil
09060-650

Status

Recruiting

Source

Faculdade de Medicina do ABC

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:32-0400

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Medical and Biotech [MESH] Definitions

Vomiting caused by expectation of discomfort or unpleasantness.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

Drugs used to prevent NAUSEA or VOMITING. Antiemetics act by a wide range of mechanisms. Some act on the medullary control centers (the vomiting center and the chemoreceptive trigger zone) while others affect the peripheral receptors.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

Symptoms of NAUSEA and VOMITING in pregnant women that usually occur in the morning during the first 2 to 3 months of PREGNANCY. Severe persistent vomiting during pregnancy is called HYPEREMESIS GRAVIDARUM.

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