The Metabolic Effects of a High Fructose Versus a High Glucose Diet in Overweight Men

2014-07-23 21:11:05 | BioPortfolio


Dietary consumption of fructose has increased by nearly 50% since 1960.

A high fructose diet (HFrD) results in greater visceral adiposity and systemic insulin resistance than a high glucose diet. The effects of fructose on liver fatty acid and ATP stores, systemic oxidative stress and cardiovascular status are not fully known.


The protocol will assess the following outcomes:

1. The ultimate fate of this increased hepatic fatty acid production following a high fructose vs. glucose diet

2. The effect of a high fructose vs. glucose diet on liver ATP stores

3. The effect of a high fructose vs. glucose diet on markers of oxidative stress

4. The effect of a high fructose vs. glucose diet on cardiovascular status

Factors critical to carbohydrate metabolism such as systemic insulin resistance, body composition, energy expenditure, physical activity will also be assessed.

32 centrally overweight healthy males with a low baseline fructose intake will be recruited. They will be randomised double blindly to receive 25% of their dietary energy requirements from either fructose or glucose for 14 days.

The sugars will first be taken in an energy balanced and then an overfeeding setting.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Bio-equivalence Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science


Hepatic Fatty Acid Metabolism


high sugar diet


School of Biomedical Sciences, University of Nottingham
United Kingdom




University of Nottingham

Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T21:11:05-0400

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