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The purpose of this study is determine whether 10-session prolonged exposure therapy delivered in massed sessions over 2 weeks (PE-M) will be an efficacious treatment for PTSD among military personnel recently returned from deployments in Afghanistan and Iraq as compared to 1) a wait list control group and 2) prolonged exposure delivered in spaced sessions over 8 weeks (PE-S).
The purpose of this study is to improve the efficiency of treatment for post-traumatic stress disorder (PTSD) with prolonged exposure (PE), an efficacious treatment for PTSD typically administered in once- or twice-weekly sessions. We will evaluate whether massing 10 PE sessions in 2 weeks (massed trials; PE-M) is more efficacious than wait list (WL), and to determine whether such massing of sessions retains the efficacy of treatment compared to 10 PE sessions spaced over 8 weeks (spaced trials; PE-S). Prolonged Exposure (PE; Foa, Hembree, & Rothbaum, 2007; Foa & Rothbaum, 1998) was developed by the PI, Edna Foa, and colleagues in the Center for the Treatment & Study of Anxiety (CTSA), University of Pennsylvania. It has been found quite efficacious in reducing PTSD and related psychopathology with various types of trauma in PTSD centers around the world. Furthermore, PE has been identified in the joint VA-Department of Defense Clinical Practice Guideline for PTSD (VA-DoD Clinical Practice Guideline Working Group, 2003) as "strongly recommended" for use with veterans with PTSD, based on the strong empirical support for PE.
This study is part of the South Texas Research Organizational Network Guiding Studies on Trauma and Resilience (STRONG STAR) (Consortium Director: Alan L. Peterson, Ph.D., ABPP, Professor, Behavioral Wellness Center for Clinical Trials, Department of Psychiatry-Mail Code 7792, University of Texas Health Science Center at San Antonio (UTHSCSA), 7703 Floyd Curl Drive, San Antonio, TX 78229-3900). Dr. Edna Foa is the overall PI of the study, and the on-site PI is Kathleen Lester, LTC, MS, Chief, Psychology Warrior Transition Brigade, Carl R. Darnall Army Medical Center, 36000 Darnall Loop, Fort Hood, TX, 76544. The study will be conducted at Fort Hood, Texas.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Posttraumatic Stress Disorders
Prolonged Exposure Therapy - Massed, Prolonged Exposure Therapy - Spaced, Wait List Control
Center for the Treatment and Study of Anxiety, University of Pennsylvania
Not yet recruiting
University of Pennsylvania
Published on BioPortfolio: 2014-08-27T03:16:39-0400
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