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Glutamine Therapy for Hemolysis-Associated Pulmonary Hypertension

2014-08-27 03:16:40 | BioPortfolio

Summary

The primary hypothesis of this study is that glutamine supplementation will improve the erythrocyte glutamine/glutamate ratio, a biomarker of oxidative stress, hemolysis and pulmonary hypertension (PH) in sickle cell disease (SCD) and thalassemia (Thal) patients with PH. PH is defined as a tricuspid regurgitant jet velocity (TRV) on Doppler echocardiography > 2.5 m/s. We also predict that glutamine therapy will increase arginine bioavailability and subsequently alter sickle red cell endothelial interaction that can be identified using endo-PAT technology through nitric oxide (NO) generation, leading to changes in biological markers, and clinical outcome. Specifically our second hypothesis is that oral glutamine will decrease biomarkers of hemolysis and adhesion molecules, and improve the imbalanced arginine-to-ornithine ratio that occurs in hemolytic anemias, leading to improved arginine bioavailability and clinical endpoints of endothelial dysfunction and PH in patients with SCD and Thal.

Study Design

Allocation: Non-Randomized, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Pulmonary Hypertension

Intervention

L-Glutamine, L-Glutamine

Location

Children's Hospital & Research Center Oakland
Oakland
California
United States
94608

Status

Recruiting

Source

Children's Hospital & Research Center Oakland

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:40-0400

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Medical and Biotech [MESH] Definitions

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