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Scandinavian Diverticulitis Trial

2014-07-23 21:11:09 | BioPortfolio

Summary

The purpose of this study is to determine whether laparoscopic lavage changes the rate of severe complications in patients with acute perforated diverticulitis who traditionally are treated with primary resection.

Description

Acute diverticulitis is a common disease in the western world. Perforation of the acute diverticulitis with peritonitis is a feared complication and standard treatment (primary sigmoid resection such as Hartmann`s procedure) still has unsatisfactory results. Both mortality and morbidity are quite high. Several uncontrolled trials have reported a lower mortality and morbidity when acute perforated diverticulitis is treated with laparoscopic lavage instead of radical surgery. We wish to conduct a randomized multicenter trial in Scandinavia in order to compare the rates of severe postoperative complications in acute perforated diverticulitis if treated by traditional primary sigmoid resection or by laparoscopic lavage. We are planning to include all patients admitted to the participating hospitals with clinical and radiological findings of acute perforated diverticulitis.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Diverticulitis

Intervention

Surgery for acute perforated diverticulitis

Location

Akershus University Hospital
Lorenskog
Norway
1478

Status

Recruiting

Source

University Hospital, Akershus

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:11:09-0400

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Medical and Biotech [MESH] Definitions

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Inflammation of the COLONIC DIVERTICULA, generally with abscess formation and subsequent perforation.

Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.

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