Advertisement

Topics

Scandinavian Diverticulitis Trial

2014-07-23 21:11:09 | BioPortfolio

Summary

The purpose of this study is to determine whether laparoscopic lavage changes the rate of severe complications in patients with acute perforated diverticulitis who traditionally are treated with primary resection.

Description

Acute diverticulitis is a common disease in the western world. Perforation of the acute diverticulitis with peritonitis is a feared complication and standard treatment (primary sigmoid resection such as Hartmann`s procedure) still has unsatisfactory results. Both mortality and morbidity are quite high. Several uncontrolled trials have reported a lower mortality and morbidity when acute perforated diverticulitis is treated with laparoscopic lavage instead of radical surgery. We wish to conduct a randomized multicenter trial in Scandinavia in order to compare the rates of severe postoperative complications in acute perforated diverticulitis if treated by traditional primary sigmoid resection or by laparoscopic lavage. We are planning to include all patients admitted to the participating hospitals with clinical and radiological findings of acute perforated diverticulitis.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Diverticulitis

Intervention

Surgery for acute perforated diverticulitis

Location

Akershus University Hospital
Lorenskog
Norway
1478

Status

Recruiting

Source

University Hospital, Akershus

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:11:09-0400

Clinical Trials [380 Associated Clinical Trials listed on BioPortfolio]

DEBUT: Diverticulitis Evaluation of Patient Burden, Utilization, and Trajectory

Half of all Americans over 60 years of age have diverticulitis of the colon. Over the last decade, the use of elective colon resection has increased by more than 50%, and diverticulitis is...

A National Study of Clinical Results After Emergency Operation for Perforated Diverticulitis

The aim of this study is to evaluate clinical results and effect on health and well-being in patients operated for perforated diverticulitis with purulent peritonitis by laparoscopic lavag...

Rifaximin Delayed Release for the Prevention of Recurrent Acute Diverticulitis and Diverticular Complications.

Colonic microbiota changes may play a key role in the pathogenesis of acute diverticulitis. A previous proof-of-concept study suggests that rifaximin, a low-absorbable oral antibiotic, may...

Diagnostic Accuracy of Bedside Ultrasound in Suspected Acute Diverticulitis

Colonic diverticulitis is a common clinical condition in patients presenting to the Emergency Department (ED) with abdominal pain. The diagnosis and staging of patients with suspected acut...

LapLAND Laparoscopic Lavage for Acute Non-Faeculant Diverticulitis

The aim of the study is to compare patient outcome following standard of care (Hartmann's or resection with anastomosis and defunctioning stoma) and a 'new therapy' (laparoscopic lavage al...

PubMed Articles [15940 Associated PubMed Articles listed on BioPortfolio]

Acute diverticulitis in renal transplant patients: should we treat them differently?

Current guidelines suggest that transplant patients with acute diverticulitis should be managed aggressively with early operative intervention to reduce morbidity and mortality. This study compared th...

Adherence to a Healthy Lifestyle is Associated With a Lower Risk of Diverticulitis among Men.

Diverticulitis is a common disease with high clinical burden. We evaluated the joint contribution of multiple lifestyle factors to risks of incident diverticulitis. We also estimated the proportion of...

Delta neutrophil index as a promising prognostic marker of emergent surgical intervention for acute diverticulitis in the emergency department.

Early identification of patients with acute diverticulitis who require emergent surgical intervention in the emergency department (ED) is important to the physician. Although computed tomography (CT) ...

12 months results of laparoscopic lavage in perforated acute diverticulitis - update of meta-analysis results new evidences, which perspectives?

A Systematic Review of Pericolic Extraluminal Air in Left-Sided Acute Colonic Diverticulitis.

Although approximately 15% of all patients with acute colonic diverticulitis have pericolic extraluminal air found on computed tomography (CT), studies on the natural course and treatment of these pat...

Medical and Biotech [MESH] Definitions

Inflammation of a DIVERTICULUM or diverticula.

Inflammation of the COLONIC DIVERTICULA, generally with abscess formation and subsequent perforation.

Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.

Surgical procedures conducted with the aid of computers. This is most frequently used in orthopedic and laparoscopic surgery for implant placement and instrument guidance. Image-guided surgery interactively combines prior CT scans or MRI images with real-time video.

Surgery which could be postponed or not done at all without danger to the patient. Elective surgery includes procedures to correct non-life-threatening medical problems as well as to alleviate conditions causing psychological stress or other potential risk to patients, e.g., cosmetic or contraceptive surgery.

More From BioPortfolio on "Scandinavian Diverticulitis Trial"

Advertisement
Quick Search
Advertisement
Advertisement

 

Searches Linking to this Trial