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A Double-blind Study of Buprenorphine Treatment of Acute Suicidality

2014-08-27 03:16:45 | BioPortfolio

Summary

The acutely suicidal patient presents a complex and dangerous clinical dilemma. Many suicidal patients receive antidepressant medications, but the onset of action of these medications is at least three weeks, and despite their established antidepressant effect, they have not shown a clear anti-suicidal benefit. Psychoanalysts hypothesized that depression (often leading to suicidality) shares important characteristics with the psychological sequelae of object loss and separation distress. Endogenous opioids (endorphins) have been implicated in mediating social bonding and separation distress in mammals. Anecdotal evidence and several clinical studies found the mixed opioid agonist-antagonist buprenorphine to be an effective antidepressant with a rapid onset of action. It is therefore hypothesized that buprenorphine may be a novel and quick-acting treatment for acute suicidality, both in the context of depression and in its absence. The proposed double-blind study will examine the effect of buprenorphine on acutely suicidal patients. Depression, suicidality, and overall functioning will be assessed before, during and after a four-week buprenorphine/placebo trial. It is hypothesized that subjects who receive the active drug will show rapid improvements in objective and subjective measures of suicidality and depression.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Suicidality

Intervention

Buprenorphine, Placebo

Location

Abarbanel MHC
Bat-Yam
Israel

Status

Recruiting

Source

University of Haifa

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:45-0400

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