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Comparison of Coronary Wedge Pressure and Collateral Flow Index Between Main Branch and Side Branch Vessels

2014-08-27 03:16:46 | BioPortfolio

Summary

The purpose of this trial is to compare the degree of collateral flow in the main vessel and the side branch vessel. Specifically, the trial will address the superiority of the recruitable collateral flow, using CFI as the surrogate marker, in the side branch compared with the main vessel.

Description

Although many interventional cardiologists are interested on how to intervene a bifurcation lesion, data on how to assess the functional significance of bifurcation lesions and which side branch vessel should be stented is largely missing. In an aspect of answering these questions, we have previously shown that a large majority of side branch vessels with significant anatomic stenosis (% stenosis≥75%) was not associated with functional impairment (FFR≥0.75), which also means that side branch vessels, compared with main vessel, may not be associated with adverse clinical outcomes, which may be the basic assumption of provisional stenting strategy for jailed side branch.

Collateral flow index (CFI=Pw-Pv/Pa-Pv) is a parameter that reflects the degree of collateral flow to the myocardium of interest and CFI<0.24 has been shown to be predictive of ischemia after balloon occlusion. Pw/Pa has also has been reported to predict ischemic vessel as accurately as CFI. Earlier studies on collateral blood flow have suggested that a cut-off value of Pw/Pa 0.30 best discriminates ischemic versus nonischemic vessel with an excellent specificity of 81%. However the value of measuring Pw/Pa or CFI in bifurcation lesions, especially in side branch vessels has never been investigated.

The purpose of this trial is to compare the degree of collateral flow in the main vessel and the side branch vessel. Specifically, the trial will address the superiority of the recruitable collateral flow, using CFI as the surrogate marker, in the side branch compared with the main vessel.

Study Design

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Conditions

Coronary Artery Disease Involving Bifurcation Lesions

Intervention

Measuring collateral flow

Location

Seoul National University Hospital
Seoul
Korea, Republic of
110-744

Status

Recruiting

Source

Seoul National University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:46-0400

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