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Skeletal Myopathy of Heart Failure

2014-07-24 14:10:22 | BioPortfolio

Summary

Patients with heart failure cannot exercise as well as those who do not have heart failure, but the exercise dysfunction is not directly attributable to heart dysfunction. Rather, exercise is limited by problems with the skeletal muscles, the muscles in the arms and legs. In this study, the investigators are testing the hypothesis that high adrenaline levels lead to characteristic changes in skeletal muscles, and that interruption of these high adrenaline levels will lead to reversal of these muscle changes and improved exercise ability.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Conditions

Heart Failure

Intervention

clonidine, clinically indicated biventricular pacemaker

Location

UCaliforniaLA
Los Angeles
California
United States
90095

Status

Recruiting

Source

University of California, Los Angeles

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:10:22-0400

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PubMed Articles [9182 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

The restoration of the sequential order of contraction and relaxation of the HEART ATRIA and HEART VENTRICLES by atrio-biventricular pacing.

Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

An alpha-2 adrenergic agonist that crosses the blood-brain barrier. Clonidine acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate. It also acts peripherally, and this peripheral activity may be responsible for the transient increase in blood pressure seen during rapid intravenous administration. (From Martindale, the Extra Pharmacopoeia, 30th ed, p350)

Heart failure caused by abnormal myocardial relaxation during DIASTOLE leading to defective cardiac filling.

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