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Measurement of Colloid Osmotic Pressure in Plasma and Interstitial Fluid in Children

2014-08-27 03:16:51 | BioPortfolio

Summary

The purpose of this study is to identify normal values of colloid osmotic pressure in interstitial fluid and plasma in healthy children between 2 and 10 years.

Description

Measurements of colloid osmotic pressure (COP) by sampling of interstitial fluid from subcutaneous tissue and plasma are well documented in animal models and human adult studies. COP plays a major role in transcapillary fluid balance and is valuable in fluid therapy planning in critically ill patients. There are no data regarding interstitial fluid COP values in neither sick nor healthy children. Sampling of interstitial fluid by the wick method in children who is under general anaesthesia (ear-nose-throat operations) gives the opportunity to identify normal COP values in this age group.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Colloid Osmotic Pressure

Location

Haukeland University Hospital
Bergen
Norway
5021

Status

Recruiting

Source

Haukeland University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:51-0400

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Medical and Biotech [MESH] Definitions

RED BLOOD CELL sensitivity to change in OSMOTIC PRESSURE. When exposed to a hypotonic concentration of sodium in a solution, red cells take in more water, swell until the capacity of the cell membrane is exceeded, and burst.

The response of cells in sensing a difference in OSMOTIC PRESSURE between the inside and outside of the cell. This response includes signaling from osmotic sensors to activate transcription factors, which in turn regulate the expression of osmocompensatory genes, all functioning to maintain CELL VOLUME and the water concentration inside the cells.

The pressure required to prevent the passage of solvent through a semipermeable membrane that separates a pure solvent from a solution of the solvent and solute or that separates different concentrations of a solution. It is proportional to the osmolality of the solution.

A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.

Solutions that have a lesser osmotic pressure than a reference solution such as blood, plasma, or interstitial fluid.

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