A Healthy Volunteer Study to Evaluate Reversibility of Induced Impairment of Cognition

2014-07-23 21:11:12 | BioPortfolio


The purpose of this study is to determine if cognitive impairment induced by scopolamine is reversed using donepezil and/or AZD1446 as compared to placebo, as assessed by electroencephalogram (EEG) measures.

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science




AZD1446, AZD1446, donepezil, Placebo


Research Site





Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T21:11:12-0400

Clinical Trials [438 Associated Clinical Trials listed on BioPortfolio]

A Study to Investigate Safety, Tolerability and Pharmacokinetics of AZD1446 Administered for 4 Weeks in Elderly Healthy Volunteers

This study is designed to evaluate the safety, tolerability and pharmacokinetics (PK) of two doses of AZD1446 or placebo in subjects when given for 4 weeks.

Study to Assess Safety, Tolerability and Pharmacokinetics After Single Doses of AZD1446 to Healthy Volunteers

The primary purpose of this study is to assess the safety and tolerability of AZD1446 following single dose administration.

4 Week, Safety and Tolerability Study in Patients With Mild to Moderate Alzheimer's Disease

The primary purpose of the study is to determine the safety and tolerability of AZD1446 vs Placebo given as an add-on treatment to Donepezil for 4 weeks in patients with mild to moderate A...

Positron Emission Tomography (PET) Study

The primary purpose is to study the occupancy at the α4β2 neuronal nicotinic receptor's (NNRs) and to determine the relation between plasma concentration of AZD1446 and the occupancy at ...

The Effect of Donepezil on Sedation and Other Symptoms

Primary Objective: 1. To determine the effectiveness of donepezil as compared to placebo for the management of opiate-induced sedation/drowsiness in patients with stable cancer pain ...

PubMed Articles [1949 Associated PubMed Articles listed on BioPortfolio]

The efficacy and safety of memantine for the treatment of Alzheimer's disease.

Currently, five pharmacotherapeutic options are available to treat Alzheimer's disease: memantine; the three cholinesterase inhibitors donepezil, galantamine, and rivastigmine; and combination treatme...

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in elderly people. Considering the multifactorial nature of AD, the concept of multi-target-directed ligands (MTDLs) has ...

The effects of donepezil on phencyclidine-induced cognitive deficits in a mouse model of schizophrenia.

Donepezil is the first-line of treatment for Alzheimer's disease (AD), which improves cognitive impairment effectively, but whether it has an impact on cognitive impairment in schizophrenia remains un...

SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization.

Research in Alzheimer's disease is going through a big turnaround. New palliative therapies are being reconsidered for the effective management of disease because of setbacks in the development of dis...

Donepezil for Compulsive Behavior in Degenerative Dementia: Case Series.

Diagnosing and managing dementia, presenting with compulsions is challenging. Presented are three cases, a possible representative subset of the Donepezil responders. Selective degeneration of dorsola...

Medical and Biotech [MESH] Definitions

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

Measures of spatial cognition and memory.

Intellectual or mental process whereby an organism becomes aware of or obtains knowledge.

Disturbances in the mental process related to thinking, reasoning, and judgment.

More From BioPortfolio on "A Healthy Volunteer Study to Evaluate Reversibility of Induced Impairment of Cognition"

Quick Search


Relevant Topic

The Top 100 Pharmaceutical Companies
Top 10 biotech and pharmaceutical companies worldwide based on market value in 2015 2015 ranking of the global top 10 biotech and pharmaceutical companies based on revenue (in billion U.S. dollars) Johnson & Johnson, U.S. 74...

Searches Linking to this Trial