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Docetaxel, Androgen Deprivation and Proton Therapy for High Risk Prostate Cancer

2014-08-27 03:16:59 | BioPortfolio

Summary

The purpose of this study is to see what effects, good and/or bad, image guided proton based radiation combined with low dose chemotherapy and hormonal therapy has on you and your cancer.

Study Design

Allocation: Non-Randomized, Control: Historical Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Prostate Cancer

Intervention

Proton Therapy , proton boost and docetaxel followed by androgen deprivation, Conformal X-ray , proton boost and docetaxel followed by androgen deprivation

Location

University of Florida Proton Therapy Institute
Jacksonville
Florida
United States
32206

Status

Recruiting

Source

University of Florida

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:59-0400

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Medical and Biotech [MESH] Definitions

A complex of enzymes and PROTON PUMPS located on the inner membrane of the MITOCHONDRIA and in bacterial membranes. The protein complex provides energy in the form of an electrochemical gradient, which may be used by either MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES or BACTERIAL PROTON-TRANSLOCATING ATPASES.

Energy that is generated by the transfer of protons or electrons across an energy-transducing membrane and that can be used for chemical, osmotic, or mechanical work. Proton-motive force can be generated by a variety of phenomena including the operation of an electron transport chain, illumination of a PURPLE MEMBRANE, and the hydrolysis of ATP by a proton ATPase. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed, p171)

Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.

Proton-translocating ATPases that are involved in acidification of a variety of intracellular compartments.

Integral membrane proteins that transport protons across a membrane. This transport can be linked to the hydrolysis of ADENOSINE TRIPHOSPHATE. What is referred to as proton pump inhibitors frequently is about POTASSIUM HYDROGEN ATPASE.

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