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Antimycotic Prophylaxis in Pediatric Patients Following Allogeneic Stem Cell Transplantation

2014-07-23 21:11:16 | BioPortfolio

Summary

Pediatric patients are at high risk to acquire mycotic infections following allogeneic bone marrow transplantation. In the present retrospective analysis we assess the safety and efficacy of different regimens in antimycotic prophylaxis.

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Conditions

Systemic Aspergillosis

Location

University Children's Hospital
Tuebingen
Germany
72076

Status

Completed

Source

University Children’s Hospital Tuebingen

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:11:16-0400

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Medical and Biotech [MESH] Definitions

Lung infections with the invasive forms of ASPERGILLUS, usually after surgery, transplantation, prolonged NEUTROPENIA or treatment with high-doses of CORTICOSTEROIDS. Invasive pulmonary aspergillosis can progress to CHRONIC NECROTIZING PULMONARY ASPERGILLOSIS or hematogenous spread to other organs.

Infections of the respiratory tract with fungi of the genus ASPERGILLUS. Infections may result in allergic reaction (ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS), colonization in pulmonary cavities as fungus balls (MYCETOMA), or lead to invasion of the lung parenchyma (INVASIVE PULMONARY ASPERGILLOSIS).

Infections with fungi of the genus ASPERGILLUS.

The sum of all nonspecific systemic reactions of the body to long-continued exposure to systemic stress.

One of the triazole ANTIFUNGAL AGENTS that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ERGOSTEROL synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.

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