Nanocort in Acute Exacerbation of Relapsing-Remitting Multiple Sclerosis (MS)
Summary
Patients with an acute exacerbation of Relapsing-Remitting Multiple Sclerosis or with Clinically Isolated Syndrome receive either one single infusion of Nanocort or three daily infusions of SoluMedrol. Main objective is to assess the occurrence of new gadolinium-enhanced T1-weighted lesions at week 8 vs week 1 after treatment.
Study Design
Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator)
Conditions
Acute Exacerbation of Remitting Relapsing Multiple Sclerosis
Intervention
PEG-liposomal prednisolone sodium phosphate, Methylprednisolone
Location
Departement Neurologie AZ St Jan AV
Brugge
Belgium
8000
Status
Recruiting
Source
Galapagos NV
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01039103
- Information obtained from ClinicalTrials.gov on July 15, 2010
Published on BioPortfolio: 2014-08-27T03:17:04-0400
Clinical Trials
Oral Glucocorticosteroid in the Treatment of Severe Asthma Exacerbation in Hospitalized Patients
A comparison of oral prednisolone administration with intravenous methylprednisolone infusion in the treatment of acute asthma exacerbation in hospitalized patients. Oral glucocorticostero...
The LIPMAT Study: Liposomal Prednisolone to Improve Hemodialysis Fistula Maturation
This study will investigate if liposomal prednisolone is effective in promoting arteriovenous fistula (AVF) maturation when administered to human subjects after surgical creation of a radi...
This study is designated to evaluate the safety and efficacy of Nanocort in subjects with active rheumatoid arthritis who are experiencing a flare/exacerbation.
- Replacement of intrathecal Triple (methotrexate, cytarabine, prednisolone) with intrathecal liposomal cytarabine and prednisolone during maintenance therapy will decrease the ...
Parasitic Ulcer Treatment Trial Pilot
This is a study of optimal treatments for acanthamoeba keratitis. In the first part of the study, participants will be randomized to chlorhexidine monotherapy or chlorhexidine plus povidon...
PubMed Articles
Pain control after total hip arthroplasty in sickle cell patients is challenging yet essential to prevent sickle cell crises or protracted hospital stays. We present a case of effective analgesia that...
Incidence of Acute Cardiovascular Event After Acute Exacerbation of COPD.
There is a lack of comprehensive view of the association between acute exacerbation of COPD (AECOPD) and the risk of acute cardiovascular events.
Importance of Acute Lymphoblastic Leukemia-type Therapy for Bilineal Acute Leukemia.
We examined 3 pediatric patients with bilineal acute leukemia. Patient 1 with B-cell acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML) with B-ALL dominance responded well to pred...
The study aimed to determine the feasibility and effectiveness of an introductory disease-specific education program delivered during an acute exacerbation of chronic obstructive pulmonary disease (AE...
Surface free energy of enamel treated with sodium hexametaphosphate, calcium and phosphate.
This study evaluated the capacity of sodium hexametaphosphate (HMP) at different concentrations to alter the surface properties of dental enamel in order to increase calcium and phosphate adsorption.
Medical and Biotech [MESH] Definitions
Methylprednisolone
A PREDNISOLONE derivative with similar anti-inflammatory action.
Sodium-phosphate Cotransporter Proteins, Type Iii
A family of highly conserved and widely expressed sodium-phosphate cotransporter proteins. They are electrogenic sodium-dependent transporters of phosphate that were originally identified as retroviral receptors in HUMANS and have been described in yeast and many other organisms.
Methylprednisolone Hemisuccinate
A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.
Sodium-phosphate Cotransporter Proteins
A family of symporters that facilitate sodium-dependent membrane transport of phosphate.
Sodium-phosphate Cotransporter Proteins, Type I
A family of sodium-phosphate cotransporter proteins that also transport organic ANIONS. They are low affinity phosphate transporters.
