Patients with an acute exacerbation of Relapsing-Remitting Multiple Sclerosis or with Clinically Isolated Syndrome receive either one single infusion of Nanocort or three daily infusions of SoluMedrol. Main objective is to assess the occurrence of new gadolinium-enhanced T1-weighted lesions at week 8 vs week 1 after treatment.
Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator)
Acute Exacerbation of Remitting Relapsing Multiple Sclerosis
PEG-liposomal prednisolone sodium phosphate, Methylprednisolone
Departement Neurologie AZ St Jan AV
Brugge
Belgium
8000
Recruiting
Galapagos NV
Published on BioPortfolio: 2014-08-27T03:17:04-0400
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Methylprednisolone
A PREDNISOLONE derivative with similar anti-inflammatory action.
Sodium-phosphate Cotransporter Proteins, Type Iii
A family of highly conserved and widely expressed sodium-phosphate cotransporter proteins. They are electrogenic sodium-dependent transporters of phosphate that were originally identified as retroviral receptors in HUMANS and have been described in yeast and many other organisms.
Methylprednisolone Hemisuccinate
A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.
Sodium-phosphate Cotransporter Proteins
A family of symporters that facilitate sodium-dependent membrane transport of phosphate.
Sodium-phosphate Cotransporter Proteins, Type I
A family of sodium-phosphate cotransporter proteins that also transport organic ANIONS. They are low affinity phosphate transporters.