Nanocort in Acute Exacerbation of Relapsing-Remitting Multiple Sclerosis (MS)
Summary
Patients with an acute exacerbation of Relapsing-Remitting Multiple Sclerosis or with Clinically Isolated Syndrome receive either one single infusion of Nanocort or three daily infusions of SoluMedrol. Main objective is to assess the occurrence of new gadolinium-enhanced T1-weighted lesions at week 8 vs week 1 after treatment.
Study Design
Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator)
Conditions
Acute Exacerbation of Remitting Relapsing Multiple Sclerosis
Intervention
PEG-liposomal prednisolone sodium phosphate, Methylprednisolone
Location
Departement Neurologie AZ St Jan AV
Brugge
Belgium
8000
Status
Recruiting
Source
Galapagos NV
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01039103
- Information obtained from ClinicalTrials.gov on July 15, 2010
Published on BioPortfolio: 2014-08-27T03:17:04-0400
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Medical and Biotech [MESH] Definitions
Methylprednisolone
A PREDNISOLONE derivative with similar anti-inflammatory action.
Sodium-phosphate Cotransporter Proteins, Type Iii
A family of highly conserved and widely expressed sodium-phosphate cotransporter proteins. They are electrogenic sodium-dependent transporters of phosphate that were originally identified as retroviral receptors in HUMANS and have been described in yeast and many other organisms.
Methylprednisolone Hemisuccinate
A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.
Sodium-phosphate Cotransporter Proteins
A family of symporters that facilitate sodium-dependent membrane transport of phosphate.
Sodium-phosphate Cotransporter Proteins, Type I
A family of sodium-phosphate cotransporter proteins that also transport organic ANIONS. They are low affinity phosphate transporters.
