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Nanocort in Acute Exacerbation of Relapsing-Remitting Multiple Sclerosis (MS)

2014-08-27 03:17:04 | BioPortfolio

Summary

Patients with an acute exacerbation of Relapsing-Remitting Multiple Sclerosis or with Clinically Isolated Syndrome receive either one single infusion of Nanocort or three daily infusions of SoluMedrol. Main objective is to assess the occurrence of new gadolinium-enhanced T1-weighted lesions at week 8 vs week 1 after treatment.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator)

Conditions

Acute Exacerbation of Remitting Relapsing Multiple Sclerosis

Intervention

PEG-liposomal prednisolone sodium phosphate, Methylprednisolone

Location

Departement Neurologie AZ St Jan AV
Brugge
Belgium
8000

Status

Recruiting

Source

Galapagos NV

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:04-0400

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Medical and Biotech [MESH] Definitions

A PREDNISOLONE derivative with similar anti-inflammatory action.

A family of highly conserved and widely expressed sodium-phosphate cotransporter proteins. They are electrogenic sodium-dependent transporters of phosphate that were originally identified as retroviral receptors in HUMANS and have been described in yeast and many other organisms.

A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.

A family of symporters that facilitate sodium-dependent membrane transport of phosphate.

A family of sodium-phosphate cotransporter proteins that also transport organic ANIONS. They are low affinity phosphate transporters.

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