Efficacy Study of VA106483 in Males With Nocturia.

2014-07-24 14:10:30 | BioPortfolio


To investigate the effect of VA106483 on nocturia related clinical outcomes compared to placebo.


Nocturia, defined as waking to urinate at least once per night between periods of sleep, is a common complaint which increases with age. VA106483 is a non-peptide drug VA106483 that is being developed for the treatment of nocturia in males.

The purpose of this study is to investigate the effect of VA106483 on the number of times the subject needs to get up to urinate (nocturnal void) per night and to determine the effect on the time between the subject's bedtime and the time they first wake up to urinate.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment






Alabama Research Center, LLC
United States


Active, not recruiting


Vantia Ltd

Results (where available)

View Results


Published on BioPortfolio: 2014-07-24T14:10:30-0400

Clinical Trials [35 Associated Clinical Trials listed on BioPortfolio]

Efficacy and Safety of VA106483 in Elderly Males

A double blind, placebo-controlled, dose ranging study in males over the age of 65, who have a history of nocturia. The study will investigate pharmacodynamic outcomes (urine volumes and o...

VA106483 and Alpha Blocker Interaction Study in Elderly Males

The main purpose of this study is to investigate whether the hypotensive effects of an alpha-blocker are increased when VA106483 is given at the same time.

VA106483 Dose Response Study in Elderly Males

The main purpose of the study is to evaluate the way VA106483 enters and leaves the blood and tissues over time and how the drug acts on and in the body at various dose levels compared to ...

Exploratory Study Evaluating the Effects of Darifenacin on Nocturia, Sleep and Daytime Wakefulness

The purpose of this study is to evaluate the efficacy of darifenacin in the treatment of moderate to severe nocturia in patients with overactive bladder and who do not have non-urologic ca...

Behavior and Exercise Versus Drug Treatment in Men With Nocturia (BEDTiMe)

Nocturia, waking at night from sleep to void, is a prevalent and troublesome symptom. Treatment with an alpha-adrenergic antagonist medication (α-blockers) is a standard therapy for LUTS ...

PubMed Articles [15 Associated PubMed Articles listed on BioPortfolio]

How can we develop a more clinically useful and robust algorithm for diagnosing and treating nocturia? ICI-RS 2017.

Nocturia, or waking up at night to void, is a highly prevalent and bothersome symptom. Currently, there is a lack of clear and consistent recommendations regarding evaluation and management of nocturi...

Nocturia in men with benign prostatic hyperplasia.

Nocturia, defined as nocturnal micturition with a frequency of at least once per night, is one of the most frequent lower urinary tract symptoms in men with benign prostatic hyperplasia (BPH) and ofte...

Efficacy of novel β -adrenoreceptor agonist vibegron on nocturia in patients with overactive bladder: A post-hoc analysis of a randomized, double-blind, placebo-controlled phase 3 study.

To investigate the efficacy of vibegron on nocturia in patients with overactive bladder.

Evaluating the efficacy and safety of silodosin on nocturia in patients with benign prostatic hyperplasia: A multi-center, prospective, open-label, single-arm, phase IV trial.

To evaluate the efficacy and safety of silodosin on nocturia in patients with benign prostatic hyperplasia (BPH).

Nocturia and night-time blood pressure: an association too frequently overlooked.

Medical and Biotech [MESH] Definitions

Frequent URINATION at night that interrupts sleep. It is often associated with outflow obstruction, DIABETES MELLITUS, or bladder inflammation (CYSTITIS).

Symptoms of disorders of the lower urinary tract including frequency, NOCTURIA; urgency, incomplete voiding, and URINARY INCONTINENCE. They are often associated with OVERACTIVE BLADDER; URINARY INCOMPETENCE; and INTERSTITIAL CYSTITIS. Lower urinary tract symptoms in males were traditionally called PROSTATISM.

More From BioPortfolio on "Efficacy Study of VA106483 in Males With Nocturia."

Quick Search


Relevant Topics

Sleep Disorders
Sleep disorders disrupt sleep during the night, or cause sleepiness during the day, caused by physiological or psychological factors. The common ones include snoring and sleep apnea, insomnia, parasomnias, sleep paralysis, restless legs syndrome, circa...

Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Searches Linking to this Trial