D-Cycloserine-Enhancer of One-Session Treatment for Phobia of Heights

2014-07-24 14:10:32 | BioPortfolio


The study will determine the effects of D-Cycloserine (DCS) on fear reduction in patients diagnosed with phobia of heights (acrophobia) undergoing one session of three hours of virtual reality exposure therapy (VRET) or in vivo exposure therapy (IVET).


The impact of D-Cycloserine on Virtual Reality Exposure Therapy (VRET) and In Vivo Exposure Therapy (IVET) for phobia of heights (acrophobia) will be tested using a randomized, double-blind, placebo-controlled trial. Eighty participants will be randomly assigned to one of the four treatment conditions: one-session VRET (3 hours) and 50 mg D-Cycloserine (VR-OST + DCS, N1=20); one-session VRET (3 hours) and placebo (VR-OST + Pl, N2=20); one-session IVET (3 hours) and placebo (IV + Pl, N3=20); or one-session IVET (3 hours) and 50 mg D-Cycloserine, (IV + DCS, N4=20). For twenty participants (5 from each group) the treatment will be delayed for three weeks and an additional assessment will be conducted as they will comprise a Wait List (WL) control group. Behavioral, cognitive and physiological changes in acrophobia will be assessed at pre-treatment, post-waitlist, post-treatment and 3 months follow-up.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment


Height Phobia


In Vivo Exposure Therapy, Virtual Reality Exposure Therapy, D-Cycloserine, Placebo


West Virginia University School of Medicine Charleston Division
West Virginia
United States




CAMC Health System

Results (where available)

View Results


Published on BioPortfolio: 2014-07-24T14:10:32-0400

Clinical Trials [3865 Associated Clinical Trials listed on BioPortfolio]

360° - Video Virtual Reality Exposure Therapy Study

This study seeks to examine a Virtual Reality Exposure Therapy (VRET) using the 360° Video Virtual Reality (VR) technology for the fear of heights and fear of spiders.

Virtual Reality Exposure Therapy for Speech Anxiety Using Commercial Hardware and Software

Virtual Reality Exposure Therapy (VRET) is an efficacious treatment of fear and anxiety, but because of the high financial costs and technical complexity of the past generation of VR hardw...

Virtual Reality Exposure Therapy for Combat

This non inferiority trial will compare Prolonged Exposure with Virtual Reality Exposure Therapy in adult patients with combat related PTSD.

Virtual Reality Immersive Method for Spider (Phobia) Exposure Therapy (VIMSE)

The aim of this study is to examine the efficacy of virtual reality exposure therapy as a treatment for specific phobia (spiders). A gamified virtual reality simulation of one-session ther...

Virtual Reality and D-Cycloserine in Combat Related Psycological Trauma in Burn Service Members

The purpose of this pilot study is to begin the examination of the feasibility of using Gradual Virtual Reality Exposure Therapy and D-Cycloserine (DCS) in the management of posttraumatic ...

PubMed Articles [23422 Associated PubMed Articles listed on BioPortfolio]

Virtual reality exposure therapy for fear of driving: analysis of clinical characteristics, physiological response, and sense of presence.

To investigate the reactions of women with driving phobia to a therapeutic program of scheduled virtual reality exposure treatment (VRET) sessions.

Applications of virtual reality in individuals with alcohol misuse: A systematic review.

Alcohol use and misuse have been intensively studied, due to their negative consequences in the general population. Evidence-based literature emphasizes that alcohol craving plays a crucial role in th...

Trauma management therapy with virtual-reality augmented exposure therapy for combat-related PTSD: A randomized controlled trial.

Virtual reality exposure therapy (VRET) realistically incorporates traumatic cues into exposure therapy and holds promise in the treatment of combat-related posttraumatic stress disorder (PTSD). In a ...

The continuous vs discontinuous use of restorative safety behaviors on symptoms of contamination fear: An experimental investigation.

Cognitive-behavioral theorists posit that safety behaviors (SBs) interfere with important exposure processes and should be removed from therapy. However, there is growing evidence to suggest that rest...

Th17/T regulator cell balance and NK cell numbers in relation to psychosis liability and social stress reactivity.

Psychotic disorders are characterized by a deranged immune system, including altered number and function of Natural Killer (NK) and T cells. Psychotic disorders arise from an interaction between genet...

Medical and Biotech [MESH] Definitions

Treatment technique in a virtual environment which allows the participant to experience a sense of presence in an immersive, computer-generated, three-dimensional, interactive environment that minimizes avoidance behavior and facilitates emotional involvement. (from Curr Psychiatry Rep (2010) 12:298)

Organs which might be damaged during exposure to a toxin or to some form of therapy. It most frequently refers to healthy organs located in the radiation field during radiation therapy.

Therapy using oral or topical photosensitizing agents with subsequent exposure to light.

Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.

A method for extinguishing anxiety by a saturation exposure to the feared stimulus situation or its substitute.

More From BioPortfolio on "D-Cycloserine-Enhancer of One-Session Treatment for Phobia of Heights"

Quick Search


Relevant Topic

Anxiety Disorders
Anxiety is caused by stress. It is a natural reaction, and is beneficial in helping us deal with tense situations and pressure. It is deterimental when is becomes an excessive, irrational dread of everyday situations. The most common types of anxiety di...

Searches Linking to this Trial