Oral Mucositis in Patients Undergoing Antineoplastic Chemotherapy

2014-08-27 03:17:07 | BioPortfolio


The purpose of this study is:

1. To investigate the feasibility of using photothermal camera and infrared (IR) thermometer to grade the severity of oral mucositis in patients with multiple myeloma undergoing chemotherapy.

2. To obtain preliminary data on the most optimal method of scoring the severity of oral mucositis by comparing the results obtained using the photothermal camera and the IR thermometer to the World Health Organization (WHO) mucositis grading system and the patient self-assessment questionnaire.

3. To Investigate the correlation between the quantitative readings obtained from oral mucosa with photothermal camera and the IR thermometer.


Several grading systems for oral mucositis are available including those of the World Health Organization (WHO), Radiation Therapy Oncology Group (RTOG), Western Consortium for Cancer Nursing Research WCCNR, and the National Cancer Institute Common Toxicity Criteria (NCICTC) and others However, all of these oral mucositis grading systems rely on visual examination and are therefore subjective and operator-dependent tools and suffer from significant interpersonal variability (6). With the current improvements in medicine and technology, there is definitely a need for a more objective, easy to perform, non-invasive, affordable, quantitative and reproducible tool that is operator-independent to assess the severity of oral mucositis. The introduction of such a tool would greatly improve our ability to compare the oral mucosal toxicity of antineoplastic therapies and the efficacy of various mucoprotective therapies. Furthermore, the use of such a tool can be extended to patients undergoing radiation treatment with or without chemotherapy for various malignancies including head and neck cancers.

Study Design

Observational Model: Case Control, Time Perspective: Prospective


Oral Mucositis


University of Arkansas for Medical Sciences
Little Rock
United States




University of Arkansas

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:17:07-0400

Clinical Trials [336 Associated Clinical Trials listed on BioPortfolio]

Low-energy Laser Therapy for Prevention of Oral Mucositis in Children

Oral mucositis represents a major complication of cytotoxic chemotherapy among cancer in children. Low-power laser therapy (LPLT) has been used to reduce the incidence of oral mucositis in...

Cox-2 Inhibition in Radiation-induced Oral Mucositis

Oral mucositis refers to ulcerative lesions of the oral mucosa that occur due to radiation therapy given for treatment of head and neck cancer. These lesions are painful, compromise nutrit...

A Phase II Controlled Trial of Velafermin for Prevention of Oral Mucositis

CG53135-05 (velafermin), a recombinant human fibroblast growth factor-20 (rhFGF-20) protein, is under investigation for the prevention of oral mucositis. Oral mucositis is a commonly occu...

Cobiprostone for the Prevention of Oral Mucositis in Subjects With HNC Receiving Concurrent RT/CT

To evaluate the efficacy, safety, and pharmacokinetics (PK) of liquid cobiprostone in preventing oral mucositis, when administered topically to the oral mucosa via spray for the duration o...

Effect of Oral Vitamin C in Assessing the Severity of Oral Mucositis in Chemoradiation of Head and Neck Cancers

The surrounding controversies both advocating and simultaneously opposing the use of vitamin C, mostly extrapolating animal models to human models, it has not been used individually to ass...

PubMed Articles [3926 Associated PubMed Articles listed on BioPortfolio]

The Effect of Oral Care Using an Oral Health Care Guide on Preventing Mucositis in Pediatric Intensive Care.

To evaluate the effectiveness of standard-of-care oral care guides developed specifically for children in intensive care to prevent mucositis.

A Mouse Model for Oral Mucositis Induced by Cancer Chemotherapy.

Oral mucositis (OM), one of the side-effects induced by chemotherapy, has 40% incidence and the incidence rate increases to approximately 100% in combination with radiotherapy. We describe OM in ICR m...

The Prevalence and Investigation of Risk Factors of Oral Mucositis in a Pediatric Oncology Inpatient Population; a Prospective Study.

Oral mucositis can be a frequent and severe complication of chemotherapy in children. It can result in pain, infection, depression, prolonged admission, treatment delays, increase in patient morbidity...

Perforation in Submucous Cleft Palate Due to Methotrexate-Induced Mucositis in a Patient With Rheumatoid Arthritis.

Spontaneous palatal perforation can be rarely developed by several causes, such as tumor, trauma, and infection. This article reports a patient with large mid-palatal perforation after suffering from ...

Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.

Oral mucositis is a common adverse effect of chemotherapy that limits the required dose of chemotherapeutic agents. Numerous attempts to mitigate chemotherapy-induced oral mucositis have failed to ide...

Medical and Biotech [MESH] Definitions

A branch of dentistry dealing with diseases of the oral and paraoral structures and the oral management of systemic diseases. (Hall, What is Oral Medicine, Anyway? Clinical Update: National Naval Dental Center, March 1991, p7-8)

The practice of personal hygiene of the mouth. It includes the maintenance of oral cleanliness, tissue tone, and general preservation of oral health.

An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).

Disorders of the mouth attendant upon non-oral disease or injury.

A dental specialty concerned with the diagnosis and surgical treatment of disease, injuries, and defects of the human oral and maxillofacial region.

More From BioPortfolio on "Oral Mucositis in Patients Undergoing Antineoplastic Chemotherapy"

Quick Search


Relevant Topic

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Searches Linking to this Trial