GSK618334 Repeat Dose Study

2014-08-27 03:17:07 | BioPortfolio


The proposed study will evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of repeated oral doses of GSK618334 in healthy male and female volunteers.


GSK618334 strongly binds to dopamine type 3 receptors in the human brain and is being developed as an innovative treatment for substance dependence. This study will evaluate the safety, tolerability, blood concentrations and effect following repeated oral doses of GSK618334 in healthy male and female volunteers. The effect of food on a single oral dose of GSK618334 will also be evaluated. Another portion of this study will investigate dopamine type 3 receptor binding in the human brain by PET scan before and after repeated doses of GSK618334.

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator)




GSK618334 High Dose, GSK618334 Medium Dose, GSK618334 PET subjects, GSK618334 Low Dose


GSK Investigational Site
United Kingdom
NW10 7EW





Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:17:07-0400

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