Training in Goal-directed Attention Regulation for Individuals With Brain Injury

2014-08-27 03:17:11 | BioPortfolio


Brain injuries affect the lives of numerous veterans. This study examines how the brain is affected by injury and how rehabilitation training for attention dysfunction may change brain functioning.


Traumatic brain injuries (TBI) are a leading cause of long-term disability among combat veterans. The most common and persistent sequelae after TBI are cognitive-behavioral deficits in 'executive control' and 'attention' functions. Such abnormalities may directly contribute to poor long-term outcomes as well as impede rehabilitation of dysfunction in other cognitive and motor domains. Effective treatments would potentially make a major impact in improving functional outcomes, but consistently effective treatments are not available. Currently, there exists no solid theoretical basis for guiding treatment development. Thus, the overall goal of this research is to improve our understanding of plasticity in brain function after TBI and to develop improved cognitive neurorehabilitation treatments based on these analyses.

What specific neural changes support improvements in executive and attention control processes? As trauma may result in injuries that affect not only cortical regions, but also sub-cortical connections, we will test a framework that incorporates the importance of brain network interactions and generates testable hypotheses regarding mechanisms of brain plasticity. Advanced functional MRI methods will be used to assay the effects of training interventions designed to address problems with attention and executive control functioning. The intervention involves group-based training in attention regulation and goal management.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment


Brain Injury


training in goal-directed attention regulation, brain health education


VA Northern California HCS
United States




Department of Veterans Affairs

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:17:11-0400

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