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1. To establish a demographic database to evaluate the efficacy of medical interventions in patients and relatives who carry BRCA1 and 2 mutations and to compare these outcomes to patients who do not carry a BRCA1 or 2 mutation.
2. To obtain blood samples from patients who undergo genetic testing to a) evaluate the incidence of genetic modifier polymorphisms involved in the development of cancer in BRCA1 and 2 mutation carriers and to compare this incidence to non-BRCA 1 and 2 carriers. b) to understand the interaction of genetic modifiers and BRCA1 and 2 in the development of cancer. c) to determine the effect of environmental influences on the incidence of polymorphisms in genetic modifiers and on the penetrance of BRCA1 and 2 mutations by linking information from our demographic database to blood samples and
3. to obtain tumor tissue from BRCA1 and 2 carriers to utilize for gene expression studies.
Observational Model: Cohort, Time Perspective: Prospective
Blood draw, Tumor tissue biopsy
Stanford University School of Medicine
Active, not recruiting
Published on BioPortfolio: 2014-08-27T03:17:12-0400
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