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Genetic & Pathological Studies of BRCA1/BRCA2: Associated Tumors & Blood Samples

2014-08-27 03:17:12 | BioPortfolio

Summary

1. To establish a demographic database to evaluate the efficacy of medical interventions in patients and relatives who carry BRCA1 and 2 mutations and to compare these outcomes to patients who do not carry a BRCA1 or 2 mutation.

2. To obtain blood samples from patients who undergo genetic testing to a) evaluate the incidence of genetic modifier polymorphisms involved in the development of cancer in BRCA1 and 2 mutation carriers and to compare this incidence to non-BRCA 1 and 2 carriers. b) to understand the interaction of genetic modifiers and BRCA1 and 2 in the development of cancer. c) to determine the effect of environmental influences on the incidence of polymorphisms in genetic modifiers and on the penetrance of BRCA1 and 2 mutations by linking information from our demographic database to blood samples and

3. to obtain tumor tissue from BRCA1 and 2 carriers to utilize for gene expression studies.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Ovarian Cancer

Intervention

Blood draw, Tumor tissue biopsy

Location

Stanford University School of Medicine
Stanford
California
United States
94305

Status

Active, not recruiting

Source

Stanford University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:12-0400

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