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It is important that people with MS maintain a level of physical conditioning that will
- allow them to live life to the fullest
- reduce the impact of MS and its course on physical functioning.
Current evidence supports rehabilitation to reduce disability but there is insufficient evidence to guide regular comprehensive exercise programs for functional optimization and health promotion. The primary objective of the study is to provide preliminary evidence for feasibility and efficacy of a MS tailored exercise program (MSTEP) in comparison to no exercise in enhancing walking endurance among sedentary persons with MS.
Objective: The purpose of this study is to provide preliminary evidence for feasibility and efficacy of a MS tailored exercise program (MSTEP) in enhancing walking endurance. Methods: The proposed pilot study is a single-blind, parallel-group, pilot randomized controlled trial. Subjects will be randomized to either the 8-week MS-Tailored Program (MSTEP) or delayed entry control group. Subjects: A total of 38 community-dwelling ambulatory persons (age between 19 and 65) diagnosed with probable or definite MS or CIS after 1994 was identified using a MS registry located at the participating MS clinic in Montreal, Canada for the previous exercise barrier study. The target population will be people who are currently sedentary. Measures: The primary outcome is walking endurance assessed by the modified 6 Minute Walk Test. The secondary outcomes are patient reported outcomes (PROs) of perceived fatigue and health and health related quality of life. Intervention: The MSTEP, designed in conjunction with input from patients with MS, is unique in that it targets all the common problems of MS (such as reduced aerobic capacity, strength, and balance) and the program is designed to avoid fatigue or heat exhaustion. It consists of five different types of exercises of which one is selected each day and done in short bursts (i.e. 5 to 10 minutes per session), in addition to the regular aerobic or endurance exercise. The program is designed to give participants freedom to choose their daily exercise. Originality and Significance of the Proposed Project: This project is designed to establish new strategies to prescribe regular and comprehensive exercise for patients with MS. It is our hope that these finding will help shape health policy and give health care professional new tools to prescribe exercise for the people they care for.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor)
Multiple Sclerosis Tailored Exercise Program
McGill University Health Centre - Royal Victoria Hospital Site
Not yet recruiting
Published on BioPortfolio: 2014-08-27T03:17:17-0400
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Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease. Over time, symptoms accumulate leading to increased disability of patients.
A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)
A non-glycosylated form of interferon beta-1 that has a serine at position 17. It is used in the treatment of both RELAPSING-REMITTING MULTIPLE SCLEROSIS and CHRONIC PROGRESSIVE MULTIPLE SCLEROSIS.
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
The most common clinical variant of MULTIPLE SCLEROSIS, characterized by recurrent acute exacerbations of neurologic dysfunction followed by partial or complete recovery. Common clinical manifestations include loss of visual (see OPTIC NEURITIS), motor, sensory, or bladder function. Acute episodes of demyelination may occur at any site in the central nervous system, and commonly involve the optic nerves, spinal cord, brain stem, and cerebellum. (Adams et al., Principles of Neurology, 6th ed, pp903-914)
Multiple protein bands serving as markers of specific ANTIBODIES and detected by ELECTROPHORESIS of CEREBROSPINAL FLUID or serum. The bands are most often seen during inflammatory or immune processes and are found in most patients with MULTIPLE SCLEROSIS.
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