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There is little information on the effect of oral bioactive compounds on human skin clinically despite evidence of a beneficial effect from laboratory studies. The aim of this study is to examine the effect of oral bioactive compounds (green tea and vitamin C) on the health of human skin by measuring markers of skin health directly and skin nutrient uptake.
There is little information on the effect of oral catechin, a nutritionally relevant bioactive compound, on skin health in humans in vivo despite considerable evidence for protective effects in experimental studies. Vitamin C is essential for skin health and stabilises catechins in the gut lumen. Ultraviolet radiation (UVR) in sunlight is a key environmental stressor impacting on skin health. Effects include acute inflammation and longer term photodamage.
OBJECTIVE: To examine the protective effect of catechin and vitamin C on UVR-induced inflammation.
STUDY DESIGN: A double-blind randomised controlled nutritional study in 90 healthy volunteers. Volunteers will receive 3 months dietary supplement with high dose bioactive (n=30), low dose bioactive (n=30) or placebo (n=30).
The aim is to quantify the influence of catechin/vitamin C on:
1. UVR-induced inflammation
2. Leukocyte infiltration
3. Inflammatory mediators
4. Markers of photoageing
The bioavailability of catechin and vitamin C in skin will also be assessed.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Green tea + vitamin C high dose, Green tea + vitamin C low dose, Placebo capsule
Salford Royal NHS Foundation Trust
University of Manchester
Published on BioPortfolio: 2014-08-27T03:17:17-0400
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