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The purpose of this study is to compare the blood pressure lowering efficacy of a treatment regimen based on a dihydropyridine calcium-channel blocker combined with an angiotensin II type-1 receptor blocker with the recommended treatment regimen based on a low-dose thiazide diuretic combined with a beta-blocker.
Sitting systolic blood pressure (average of three readings) will be the primary outcome variable.
1. To compare the time interval between the two treatment groups, which after randomisation will be required, to reach and maintain the target defined as a blood pressure below 140 mm Hg systolic and 90 mm Hg diastolic;
2. To compare the duration of follow-up, during which a steady blood pressure control will be achieved;
3) To evaluate the incidence of adverse events, symptoms, biochemical abnormalities and ECG changes in the two treatment groups;
(4) To assess the adherence to antihypertensive treatment as well as the rate of drop-outs in both treatment arms during a six-month period.
Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
amlodipine 5/10 mg per day plus valsartan 160 mg/day, hydrochlorothiazide 12.5/25.0 mg/day plus bisoprolol 5 mg/day, Hydrochlorothiazide 12.5/25.0 mg/day plus 5 mg/day bisoprolol
Ecole de Médecine de Douala
Not yet recruiting
University of Kinshasa
Published on BioPortfolio: 2014-08-27T03:17:20-0400
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