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Bleeding Symptoms of Carriers of Hemophilia A and B

2014-08-27 03:17:23 | BioPortfolio

Summary

To collect and analyze data on female carriers of severe and moderate hemophilia A and B.

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional

Conditions

Hemophilia

Location

Department of hematology and coagulation, Sahlgrenska university hospital
Göteborg
Sweden
417 60

Status

Not yet recruiting

Source

Sahlgrenska University Hospital, Sweden

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:23-0400

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Optimization of prophylaxis for hemophilia A.

Prophylactic injections of factor VIII reduce the incidence of bleeds and slow the development of joint damage in people with hemophilia. The aim of this study was to identify optimal person-specific ...

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FIX It in One Go: Enhanced Factor IX Gene Therapy for Hemophilia B.

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Medical and Biotech [MESH] Definitions

A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008)

The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.

A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia.

Bleeding into the joints. It may arise from trauma or spontaneously in patients with hemophilia.

Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is often called hemophilia C.

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A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease. For example: to diagnose diseases to measure the progress or recovery from disease to confirm that a person is free from disease Clin...


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