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CATCH - Catheter Infections in Children

2014-08-27 03:17:24 | BioPortfolio

Summary

Most children admitted to paediatric intensive care units (PICU) need to have medicines given to them into their veins using a narrow tube, so they do not need repeated injections. This tube is called a central venous catheter. Occasionally these catheters can cause infections in the blood and sometimes the tubes can get blocked by small blood clots.

Some intensive care units already use antibiotic or heparin coated catheters, but there is no proof that these are better than the standard ones at preventing infections. Most of the PICU's in this country use standard lines. The only way to find out for certain is to compare children who are given antibiotic or heparin coated catheters with those who are given standard ones in a clinical trial. Because we do not know which type of catheter is best, the type of catheter each child receives in the study will be decided randomly by chance.

Each child in the trial will have the same chance of getting any of these three catheters:

- Standard central venous catheter (not coated).

- Heparin coated central venous catheter. Heparin is a medicine that can stop blood from clotting and might stop the tubes being blocked and infections in the blood.

- Antibiotic coated central venous catheter. Antibiotics can be used to kill bacteria which cause the infections.

The aim of this study is to see how the three types of catheters compare in reducing the amount of blood infections in children. We will also look at the costs involved. We hope to recruit 1200 children in the UK over 2 years. We hope that the information we get from this study will guide policy about purchasing impregnated Central Venous Catheters across the NHS and thereby improve treatment for children in the future.

Study Design

Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention

Conditions

Catheter-Related Infections

Intervention

Standard polyurethane Central Venous Catheter, Antibiotic impregnated polyurethane CVC (minocycline and rifampicin), Heparin bonded polyurethane CVC

Location

Institute of Child Health
London
United Kingdom
WC1N 1EH

Status

Not yet recruiting

Source

Institute of Child Health

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:24-0400

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PubMed Articles [11446 Associated PubMed Articles listed on BioPortfolio]

Association of Proteinuria with Central Venous Catheter Use at Initial Hemodialysis.

Central venous catheter (CVC) use is associated with increased mortality and complications in hemodialysis recipients. Although prevalent CVC use has decreased, incident use remains high.

Ultrasound-Guided Peripheral Intravenous Catheters to Reduce Central Venous Catheter Use on the Inpatient Medical Ward.

The traditional technique of placing a peripheral intravenous (IV) catheter is successful in most cases on inpatient wards. However, when the traditional method fails, a central venous catheter may be...

Study protocol for a multicentre, randomised, controlled trial to assess the effectiveness of antimicrobial central venous catheters versus ordinary central venous catheters at reducing catheter related infections in critically ill Chinese patients.

Catheter use is associated with many complications and is an iatrogenic source of morbidity and mortality in intensive care units (ICU). The catheter being studied (Certofix Protect) was developed to ...

Haemodialysis catheter related central venous thrombosis; Clinical approach to evaluation and management.

Central venous catheter use is common among patients undergoing haemodialysis. Catheter related vascular thrombosis is a frequent complication, which results in catheter dysfunction. This may eliminat...

Risk of Venous Thromboembolism Following Peripherally Inserted Central Catheter Exchange: an Analysis of 23,000 Hospitalized Patients.

Catheter exchange over a guidewire is frequently performed for malfunctioning peripherally inserted central catheters (PICCs). Whether such exchanges are associated with venous thromboembolism is not ...

Medical and Biotech [MESH] Definitions

Placement of an intravenous catheter in the subclavian, jugular, or other central vein for central venous pressure determination, chemotherapy, hemodialysis, or hyperalimentation.

Skin irritant and allergen used in the manufacture of polyurethane foams and other elastomers.

A soft, loose-fitting polyurethane sheath, closed at one end, with flexible rings at both ends. The device is inserted into the vagina by compressing the inner ring and pushing it in. Properly positioned, the ring at the closed end covers the cervix, and the sheath lines the walls of the vagina. The outer ring remains outside the vagina, covering the labia. (Med Lett Drugs Ther 1993 Dec 24;35(12):123)

The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.

Impaired venous blood flow or venous return (venous stasis), usually caused by inadequate venous valves. Venous insufficiency often occurs in the legs, and is associated with EDEMA and sometimes with VENOUS STASIS ULCERS at the ankle.

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