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A Trial to Compare the Efficacy of Two Formulations of Avotermin Against Placebo

2010-07-15 17:00:00 | BioPortfolio

Summary

RN1006 has been developed as a stabilized formulation of avotermin which, when dosed once in pre-clinical studies in animals, has shown comparable scar improvement efficacy to the standard twice-dosed Juvista formulation. The aim of this trial is to investigate the efficacy of RN1006 compared to Juvista in a human volunteer model

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Conditions

Scar Improvement

Intervention

Juvista (Avotermin), RN1006 (Avotermin), RN1006 (Avotermin), RN1006 (Avotermin), Juvista (Avotermin), Juvista (Avotermin), Juvista (Avotermin), RN1006 (Avotermin), Placebo

Location

Renovo CTU
Manchester
United Kingdom
M13 9XX

Status

Active, not recruiting

Source

Renovo

Results (where available)

View Results

Links

Published on BioPortfolio: 2010-07-15T17:00:00-0400

Clinical Trials [17 Associated Clinical Trials listed on BioPortfolio]

Safety Study of Repeated, Escalating Doses of Intradermal Avotermin (Juvista)

The purpose of this study is to determine the safety and local toleration and histological effects of various dose levels of avotermin (Juvista) injected intradermally in healthy male volu...

Genomic Changes Associated With the Use of Intradermal Avotermin (Juvista) in Small Wounds in Healthy Male Subjects

The purpose of this study is to further determine the safety and toleration of intradermal avotermin (Juvista), confirm accelerated healing and investigate genomic expression profiles

Juvista in Scar Revision Surgery of Disfiguring Scars

This trial is to determine whether Juvista can prevent scar formation or improve the appearance of scars following scar revision surgery. The trial will involve comparing Juvista to placeb...

Investigation of the Safety, Dosing Frequency and Anti-Scarring Potential of Two Concentrations of Intradermal Avotermin (Juvista)

The purpose of this study is to investigate the dosing frequency, wound healing (re-epithelialisation) and anti-scarring effects of one, three and five applications of two concentrations o...

Investigation of the Accelerated Healing and Anti-scarring Potential of Avotermin (Juvista) in Split Skin Graft Donor Sites

The purpose of this study is to investigate the accelerated-healing potential of injection or injection plus topical application of Juvista to minor split skin grafts (SSG).

PubMed Articles [0 Results]

None

Medical and Biotech [MESH] Definitions

None available.

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