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We hypothesize that p16 hypermethylation in tumor and adjacent non-tumor mucosa identifies patients who have impaired response to stress signals associated with smoking, and that p16 hypermethylation and associated over expression of downstream targets such as COX-2, VEGF, EGFR and IL6 can be abrogated by soy isoflavone supplementation.
The overall long term goal of the proposed research is to determine if administration of a soy isoflavone will provide a basis for secondary prevention and cancer control that can decrease tumor recurrence and increase overall survival and quality of life in patients with head and neck squamous carcinoma. Secondarily, we hope to identify candidate genes and intermediate endpoints for future primary prevention trials. The inclusion of Karmanos Cancer Institute and Emory University will provide additional new patient accrual and improved access to minority patients.
We will conduct a Phase II trial to determine whether short term (3 weeks) soy isoflavone administration can modulate p16 methylation and tissue expression of p53, p16, EGFR, VEGF, Bcl-xL and COX-2 in resected specimens and adjacent non-tumor mucosa to potentially identify markers useful as intermediate endpoints and define how quickly changes in gene markers might be seen. Correlation of pretreatment tissue markers with serum and saliva markers will be determined to identify potential surrogates of tissue markers that could be useful in serial monitoring protocols in patients or high risk populations with oral leukoplakia or dysplasia where serial tumor specimens are not available. This protocol is designed to provide a comprehensive assessment of adjuvant soy isoflavone and molecular markers in a prospective clinical trial setting. Accrual will be enhanced by the addition of Karmanos Cancer Institute and Emory University.
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
University of Michigan Health System
University of Michigan Cancer Center
Published on BioPortfolio: 2014-08-27T03:17:26-0400
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Aim of the study is to verify wether it is possible to have a more sensitive diagnostic tool using pancytokeratin immunohistochemistry for desmoplastic squamous cell carcinoma compared to ...
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Squamous Cell Carcinoma of the Head and Neck (SCCHN) is a devastating illness, the treatment of which is associated with significant morbidity. This type of cancer affects 43,000 individua...
A few cases of pigmented squamous cell carcinoma affecting the skin and the ocular and oral mucosa of the elderly have been described in the literature. The disease manifests itself as papular and nod...
This study aimed to construct a prediction model for cervical squamous cell carcinoma and evaluate its accuracy in diagnosing cervical squamous cell carcinoma.
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A carcinoma derived from stratified squamous epithelium. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Primary urethral carcinomas are rare and typically of squamous cells. Urethral carcinoma is the only urological malignancy that is more common in females than in males.
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Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...