Intensive Computerized Brain Training (ICBT) in Youth With Early Onset Schizophrenia and Schizoaffective (EOSS)

2014-08-27 03:17:26 | BioPortfolio


The purpose of this study is to examine whether an intensive computerized intervention targeted on improving central auditory and visual processing and executive functioning can be implemented in youths aged 10-17 with schizophrenia spectrum disorders, what developmental modifications are needed particularly for the younger participants, and whether it is possible to develop an appropriate, blinded control intervention.


The purpose of this study is to provide a foundation for future rigorous study of an intervention that translates what we know about refinement of synaptic connections in response to environmental stimuli to an individualized intervention that directly improves neurocognitive functioning in youths with early onset schizophrenia and schizoaffective disorder (EOSS). We will conduct a pilot randomized control study that determines the feasibility, tolerability and acceptability of Intensive Computerized Brain Training (ICBT) in youth with EOSS.

Participants: Sixty youths, aged 10 years to 17 years inclusive will be assessed in the study. Forty youths with EOSS will be randomly assigned to ICBT or an equally intense computerized game activity and 20 will be age, gender and race matched youths with no major psychiatric illnesses.

Procedures (methods): The forty participants with EOSS will be randomly assigned to treatment with ICBT or equally intense video game play that also involves attention to sensory stimuli and requires increasingly skilled responses. A computer generated randomization schedule will be used to make assignments. Outcomes will be assessed at baseline, completion of the intervention (week 20), month 8 (3 after completing the intervention) and month 12 (7 months after completing the intervention). The other 20 youths, who comprise the typically developing comparison group known as healthy controls, will not participate in the computer activity or regular monthly psychiatric visits and will not complete satisfaction questionnaires.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment




ICBT Program


University of North Carolina, Chapel Hill
Chapel Hill
North Carolina
United States




University of North Carolina, Chapel Hill

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:17:26-0400

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