Track topics on Twitter Track topics that are important to you
The overall purposes of this research are to determine if Cognitive Behavioral Therapy (CBT) has the same healing effect on the brain for people with depression as traditional anti-depressants do, to find out more about the causes of depression and why people differ in the extent of problems caused by depression, and to determine if certain differences in genes within populations are related to clinical symptoms. We hypothesize that CBT will have the same healing effect on the brain as antidepressants; that differences in brain activations created by the various tasks and genetic differences will help us understand differences in the type and severity of symptoms among the depressed subjects.
The overall purposes of this research are to determine if Cognitive Behavioral Therapy (CBT) has the same healing effect on the brain for people with depression as traditional anti-depressants do, to find out more about the causes of depression and why people differ in the extent of problems caused by depression, and to determine if certain differences in genes within populations are related to clinical symptoms.The genes we are examining for this study are called "COMT, BDNF, and 5-HTT long arm and short arm", as well as future genes that may be discovered to play a role in depression at a later time, and will be determined by examining a sample of your saliva and a small blood sample. The method we are using to study depression is Functional Magnetic Resonance Imaging (fMRI) which takes pictures of the brain. This method allows us to identify certain parts of the brain that show how the brain works in controlling negative feelings. These pictures will compare 50 depressed individuals with 50 individuals who are not depressed.
Three tasks will be performed during the scan which are designed to cause activations in the brain areas we are interested in. In the first task, subjects will do a matching task in which the stimuli to match are either faces or houses and in which flanking distracters are either faces or houses. The goal of participants in this task is to attend to stimuli in either the horizontal or the vertical plane. On each trial, non-task relevant stimuli (distracters) are presented in the non-attended plane. One some trials these distracter stimuli are houses, on some trials neutral faces and on some trials they are negative faces. In the second task, participants will be presented with pre-recorded statements using words from the list of 555 personality/trait words compiled by Anderson (1968). Examples of these statements are "I am happy", "You are lucky", "You are dull", and "You are greedy". For negative statements, participants will be instructed to either passively listen to the statement or decrease their emotional response to the statement. For neutral statements, participants will be asked to passively listen to the statements.Subjects will then be asked how much the statement applies to them, on a 4-part Likert-type scale. In the third task, subjects will be asked to focus all their attention on a single fixation point. This will allow us to measure their resting state connectivity between specific brain regions.
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor)
Sertraline, Cognitive Behavioral Therapy
National Institute of Mental Health (NIMH)
Published on BioPortfolio: 2014-08-27T03:17:26-0400
This study was designed to determine if the novel combination of the SSRI, sertraline, and the NRI reboxetine will increase antidepressant efficacy without sacrificing the favorable safety...
The purpose of the study is to examine the effects of a form of talk therapy called cognitive behavior therapy (CBT) in the treatment of major depression in individuals with Parkinson's di...
To study the effectiveness of sertraline (Zoloft) in treating depression in adults with diabetes. The study will also determine whether depressed diabetic patients who have successfully r...
This study will evaluate the benefit of adding sertraline (Zoloft®) to trauma-focused Cognitive Behavioral Therapy (TF-CBT) for sexually abused children who have Posttraumatic Stress Diso...
This multicenter study aims to investigate the safety and efficacy of cimicoxib, a selective COX-2 inhibitor, in combination with sertraline compared to sertraline combined with placebo in...
Cognitive behavioral therapy (CBT) is effective in the treatment of major depressive disorder (MDD). Transcranial Direct Current Stimulation (tDCS) has demonstrated preliminary antidepressant effects ...
Depression during pregnancy is a significant public health problem that is associated with adverse consequences for women and children. Despite the availability of treatment options, depression during...
The present study evaluated the combined effectiveness of cognitive behavioral therapy (CBT) for postnatal depression. A systematic search was conducted across databases including PubMed, Embase, and ...
We have developed a structured cognitive behavioral therapy manual for anxiety disorder in China, and the present study evaluated the applicability of simplified cognitive behavioral therapy based on ...
Previous studies on self-esteem and depression demonstrated the usefulness of both implicit and explicit self-esteem as well as their congruence (also known as self-esteem consistency) to predict futu...
A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.
Contextually focused form of cognitive behavioral psychotherapy that uses MINDFULNESS and behavioral activation to increase patients' psychological flexibility in areas such as ability to engage in values-based, positive behaviors while experiencing difficult thoughts, emotions, or sensations.
A selective serotonin uptake inhibitor that is used in the treatment of depression.
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
The use of art as an adjunctive therapy in the treatment of neurological, mental, or behavioral disorders.
Depression is a serious mental health condition, where sad feelings carry on for weeks or months and interfere with your life. The symptoms include feeling unhappy most of the time (but may feel a little better in the evenings), loosing interest in lif...
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase 'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...