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Safety of Phenylephrine Hydrochloride, Acetaminophen, Dimethindene Maleate Compared to Phenylephrine Hydrochloride Alone in Healthy Volunteers

2014-08-27 03:17:30 | BioPortfolio

Summary

This study will evaluate the safety of phenylephrine hydrochloride 10 mg + acetaminophen 500 mg + dimethindene maleate 1 mg compared to phenylephrine hydrocloride 10 mg alone in healthy volunteers.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator)

Conditions

Heart Rate

Intervention

Phenylephrine HCL, Phenylephrine HCL/Acetaminophen/Dimethindene Maleate

Location

Scentryphar Pesquisa Clinica Ltda.
Campinas
São Paulo
Brazil

Status

Not yet recruiting

Source

Novartis

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:30-0400

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PubMed Articles [10145 Associated PubMed Articles listed on BioPortfolio]

Phenylephrine does not improve oxygenation during one-lung ventilation: A randomized, double-blind, cross-over study.

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A Random-allocation Graded Dose-Response Study of Norepinephrine and Phenylephrine for Treating Hypotension during Spinal Anesthesia for Cesarean Delivery.

Norepinephrine has been investigated as a potential alterative to phenylephrine for maintaining blood pressure during spinal anesthesia for cesarean delivery with the advantage of less depression of m...

Upregulation of α-enolase protects cardiomyocytes from phenylephrine-induced hypertrophy.

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A calibration matrix has been developed and successfully applied to quantify actives in Children's Dimetapp®, a cough mixture whose active components suffer from heavy spectral interference. High-per...

Shock and Lethality with Anthrax Edema Toxin in Rats are Associated with Reduced Arterial Responsiveness to Phenylephrine and are Reversed with Adefovir.

Although edema (ETx) and lethal toxin (LTx) contribute to B. anthracis shock and lethality, mechanisms underlying their cardiovascular effects are unclear. We previously showed that ETx but not LTx in...

Medical and Biotech [MESH] Definitions

An alpha-adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.

Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.

A subclass of alpha-adrenergic receptors (RECEPTORS, ADRENERGIC, ALPHA). alpha-1 Adrenergic receptors can be pharmacologically discriminated, e.g., by their high affinity for the agonist phenylephrine and the antagonist prazosin. They are widespread, with clinically important concentrations in the liver, the heart, vascular, intestinal, and genitourinary smooth muscle, and the central and peripheral nervous systems.

An alpha-adrenergic blocking agent that is used in Raynaud's disease. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomimetic agents. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)

The heart rate of the FETUS. The normal range at term is between 120 and 160 beats per minute.

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