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Exelon Patch and Combination With Memantine Comparative Trial

2014-08-27 03:17:32 | BioPortfolio

Summary

The primary objective is to compare the tolerability between rivastigmine patch monotherapy and combination therapy with memantine in patients with Alzheimer's disease (AD). The secondary objective is to compare the efficacy and safety between rivastigmine patch monotherapy and combination therapy with memantine in patients with AD. The study hypothesis is that the tolerability of the combination therapy with memantine is not inferior to that of rivastigmine patch monotherapy in AD patients.

Description

Recently, the rivastigmine patch demonstrated efficacy comparable to the highest doses of rivastigmine capsules, with markedly improved tolerability profile. We hypothesized that combination of memantine and rivastigmine patch will be safe and well tolerated and result in more clinical benefit in patients with AD in comparison with rivastigmine patch monotherapy, for the mechanisms of the drugs are different.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Alzheimer's Disease

Intervention

Rivastigmine transdermal patch (Exelon patch), memantine, Rivastigmine transdermal patch

Location

The Catholic University of Korea Hospital
Bucheon
Korea, Republic of
420-767

Status

Completed

Source

Inha University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:32-0400

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Medical and Biotech [MESH] Definitions

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