Advertisement

Topics

Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients

2014-08-27 03:17:32 | BioPortfolio

Summary

A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.

Description

Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Conditions

Single-nucleotide Polymorphism (SNP) for Glaucoma

Intervention

SNP analysis of the DNA

Location

Chungnam National University Hospital
Daejeon
Korea, Republic of
301-721

Status

Completed

Source

Chungnam National University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:32-0400

Clinical Trials [430 Associated Clinical Trials listed on BioPortfolio]

Folate Gene Polymorphisms and Cellular Folate Speciation Pilot Study

This pilot study is designed to investigate differences in folate-related genes (single nucleotide polymorphisms) and their relationship to the species of folate present on red blood cells...

Single Nucleotide Polymorphism (SNP) Panels and Risk Assessment in Women Undergoing Mammography

This protocol compares use of single nucleotide polymorphism panels to common risk assessment models. Women undergoing screening mammography or breast biopsy due to BIRADS Category 4 lesi...

Molecular Analysis Of Solid Tumors

This study will prospectively characterize the molecular, cellular and genetic properties of primary and metastatic neuroblastoma, osteosarcoma, retinoblastoma, Ewing sarcoma family of tum...

The Association of Genetic Polymorphisms With Statin-Induced Myopathy.

To observe not only the distribution of single nucleotide polymorphism in genes related with pharmacodynamic and pharmacokinetics alteration of statins but also to analyze the correlation ...

Use Cord Blood Single Nucleotide Polymorphism to Predict the Later Development of Atopy and Allergy

The aim of our study was firstly to detect in cord bloods the polymorphism of genes related to atopy and allergic diseases and to examine their mutual interaction and their associations wi...

PubMed Articles [20357 Associated PubMed Articles listed on BioPortfolio]

Association of Optic Neuritis with Gene Single Nucleotide Polymorphism and IL-17A Concentration.

The aetiology and pathophysiology of optic neuritis (ON) is not absolutely clear but genetic and inflammatory factors may be also involved in its development. The aim of the present study was to deter...

Real-world Experience of Using Tag-single-nucleotide Polymorphism Assay to Screen for Axial Spondyloarthritis.

We previously published an analytical validation of the tag-single-nucleotide polymorphism (SNP) assay in based on the initial identification of the tag-SNP by the International Genetics of Ankylos...

Correlation of the single nucleotide polymorphism rs662 of PON1 with the risk of male infertility.

To investigate the correlation between the single nucleotide polymorphism (SNP) rs662 of the paraoxonase 1 gene (PON1) and the risk of male infertility.

Genetic Risk Factors for Intracranial Aneurysm in the Kazakh Population.

An intracranial aneurysm (IA) is a weak or thin area on a blood vessel in the brain that balloons as it fills with blood. Genetic factors can influence the risk of developing an aneurism. The purpose ...

A Single Nucleotide Polymorphism in the Vitamin D Receptor Gene Is Associated With Decreased Levels of the Protein and a Penetrating Pattern in Crohn's Disease.

Vitamin D signaling modulates inflammation through the vitamin D receptor (VDR). The synonymous single nucleotide polymorphism (SNP) rs731236, located in the VDR gene, has been associated with a highe...

Medical and Biotech [MESH] Definitions

The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.

A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.

Techniques of nucleotide sequence analysis that increase the range, complexity, sensitivity, and accuracy of results by greatly increasing the scale of operations and thus the number of nucleotides, and the number of copies of each nucleotide sequenced. The sequencing may be done by analysis of the synthesis or ligation products, hybridization to preexisting sequences, etc.

RESTRICTION FRAGMENT LENGTH POLYMORPHISM analysis of rRNA genes that is used for differentiating between species or strains.

The detection of RESTRICTION FRAGMENT LENGTH POLYMORPHISMS by selective PCR amplification of restriction fragments derived from genomic DNA followed by electrophoretic analysis of the amplified restriction fragments.

More From BioPortfolio on "Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Bioinformatics
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Ophthalmology
Ophthalmology is the branch of medicine that is devoted to the study and treatment of eye diseases. As well as mild visual defects correctable by lenses, ophthalmology is concerned with glaucoma, uveitis and other serious conditions affecting the eye, ...


Searches Linking to this Trial