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Observational Study on Anti-tat Immune Response in HIV-1-infected HAART-treated Adult Subjects

2014-08-27 03:17:33 | BioPortfolio

Summary

The present study is designed as a prospective observational study directed at evaluating the frequency, magnitude, quality and persistence (primary endpoint) of the anti-Tat immune response in highly active antiretroviral therapy (HAART)-receiving HIV-1 infected individuals, and to prospectively evaluate the immunological, virological and clinical outcome of anti-Tat positive versus anti-Tat negative subjects under successful HAART (secondary endpoint), in order to determine the impact of anti-Tat immunity on HIV disease progression as well as the potential use of anti-Tat immune response assessment for the clinical and therapeutic management of HAART-treated infected patients. This survey, that will evaluate a large number of subjects, will provide important information for the design, planning and conduction of future therapeutic vaccine trials based on the HIV-1 Tat protein in HAART-treated patients.

Study Design

Time Perspective: Prospective

Conditions

HIV Infection

Location

S.M. Goretti Hospital
Latina
Rome
Italy
41100

Status

Recruiting

Source

Istituto Superiore di Sanita

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:33-0400

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