GLPG0259 Solid Formulation Bioavailability and Food Effect
Summary
The purpose of the study is to compare the pharmacokinetics of GLPG0259 as a solid dosage formulation (with and without food)and an oral solution, and to assess its safety and tolerability.
Study Design
Allocation: Randomized, Control: Uncontrolled, Endpoint Classification: Bio-availability Study, Intervention Model: Crossover Assignment, Masking: Open Label
Conditions
Intervention
GLPG0259 solution, GLPG0259
Location
SGS Stuivenberg
Antwerp
Belgium
Status
Completed
Source
Galapagos NV
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01024517
- Information obtained from ClinicalTrials.gov on July 15, 2010
Published on BioPortfolio: 2014-08-27T03:17:36-0400
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Medical and Biotech [MESH] Definitions
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Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).
Healthy People Programs
Healthy People Programs are a set of health objectives to be used by governments, communities, professional organizations, and others to help develop programs to improve health. It builds on initiatives pursued over the past two decades beginning with the 1979 Surgeon General's Report, Healthy People, Healthy People 2000: National Health Promotion and Disease Prevention Objectives, and Healthy People 2010. These established national health objectives and served as the basis for the development of state and community plans. These are administered by the Office of Disease Prevention and Health Promotion (ODPHP). Similar programs are conducted by other national governments.
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The pressure required to prevent the passage of solvent through a semipermeable membrane that separates a pure solvent from a solution of the solvent and solute or that separates different concentrations of a solution. It is proportional to the osmolality of the solution.
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Solution that is usually 10 percent glucose but may be higher. An isotonic solution of glucose is 5 percent.
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The washing of the VAGINA cavity or surface with a solution. Agents or drugs can be added to the irrigation solution.
