Epigenetic Regulation of BDNF in Schizophrenia

2014-08-27 03:17:42 | BioPortfolio


In this proposal, we will (1) detect the associations between BDNF and Trk B gene DNA methylation, histone modification, psychotic symptoms, obesity, suicide and antipsychotic drug responses in Taiwanese patients (2) discuss the possible mechanisms of epigenetic regulation of BDNF and Trk B in schizophrenia patients.


A total 160 subjects (80 subjects every year, including 40 healthy controls and 40 schizophrenia patients) will be recruited during a 2-year period. The first year, the baseline data of BDNF and Trk B DNA methylation, protein and mRNA levels in all subjects will be collected and the following 1 months data will also be collected in schizophrenia with antipsychotic drug treatments. The second year, the baseline data of BDNF and Trk B histone modification in all subjects will be collected.

Study Design

Observational Model: Case Control, Time Perspective: Prospective


BDNF, DNA Methylation, Suicide, Drug Responses.


Department of Psychiatry, Chang Gung Memorial Hospital




Chang Gung Memorial Hospital

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:17:42-0400

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