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Esophageal Hypersensitivity Study in Patients With Gastroesophageal Reflux Disease (GERD)

2014-07-23 21:11:42 | BioPortfolio

Summary

The purpose of the study is to compare sensitivity of visceral pain in the esophagus using different pain stimuli.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Sensitivity in Esophagus

Intervention

AZD1386, Placebo to AZD1386

Location

Research Site
Århus C
Vastra Gotaland
Denmark

Status

Recruiting

Source

AstraZeneca

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:11:42-0400

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PubMed Articles [5183 Associated PubMed Articles listed on BioPortfolio]

Cough reflex sensitivity does not correlate with the esophageal sensitivity to acid in patients with gastroesophageal reflux disease.

The sensitization of cough reflex observed in patients with gastroesophageal reflux disease (GERD) is attributed to activation of vagal C-fibers innervating the esophagus by acid, while the heartburn ...

Prediction of Barrett's esophagus: are we there yet?

Usefulness of the "continuous insufflation method" for observing the cervical esophagus.

The cervical esophagus is the short part of the esophagus between the lower border of the cricoid cartilage and the thoracic inlet (suprasternal notch), and is ~18 cm from the incisor teeth [1]. Diffi...

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Medical and Biotech [MESH] Definitions

A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.

Abnormal passage communicating with the ESOPHAGUS. The most common type is TRACHEOESOPHAGEAL FISTULA between the esophagus and the TRACHEA.

A DIVERTICULUM at the upper end of the ESOPHAGUS through the cricopharyngeal muscle at the junction of the PHARYNX and the esophagus.

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