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Hematopoietic Stem Cell Transplantation Based on Pharmacokinetic and Pharmacodynamic Modeling

2014-08-27 03:17:49 | BioPortfolio

Summary

In this study the investigators plan to develop a method to determine optimal busulfan dose through pharmacokinetic study.

Description

Busulfan is a highly toxic drug with narrow therapeutic window used for the conditioning of hematopoietic stem cell transplantation. High exposure is associated with systemic toxicity such as veno-occlusive disease (VOD) and underexposure is associated with graft failure or relapse. In this study we plan to develop a method to determine optimal busulfan dose through pharmacokinetic study.

Study Design

Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Hematopoietic Stem Cell Transplantation

Intervention

Busulfan

Location

Seoul National University Hospital
Seoul
Daehangno, Jongno-gu
Korea, Republic of
101

Status

Recruiting

Source

Seoul National University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:49-0400

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Medical and Biotech [MESH] Definitions

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