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Simvastatin in Patients With Isolated Arterial Hypertension

2014-08-27 03:17:49 | BioPortfolio

Summary

The purpose of this study is to determine whether combined therapy with simvastatin and hypotensive drugs (ACEI or ARB) may decrease the blood pressure. Moreover, we would like to assess the influence of isolated hypertension on endothelial injury, and on the development of atherosclerosis.

Description

Hypertension is one of the most important predictors of cardiovascular diseases (CVD). Due to the fact that hypertension frequently coexists with hypercholesterolemia and diabetes which increase the risk of CVDs development, it is advisable to use the optimal combined therapy (hypotensive + hypolipidemic + hypoglycemic)in this group of patients. Statins are the most effective and widely used drugs for the treatment of hypercholesterolemia. According to the available experimental and clinical data they may decrease the blood pressure (BP) in normotensive and hypertensive patients. However, it is still difficult to determine to what degree the reduction of both blood pressure and cardiovascular risk is due to hypotensive or hypolipidemic/pleiotropic effects of statins.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Conditions

Hypertension

Location

Departament of Nephrology, Hypertension and Family Medicine, Clinical Hospital of Medical University of Lodz
Lodz
Poland
90-549

Status

Recruiting

Source

Medical Universtity of Lodz

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:49-0400

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