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Interstitial Lung Abnormalities in Renal Transplant Recipients

2014-07-24 14:10:51 | BioPortfolio

Summary

Immunosuppressive drugs such as tacrolimus, cyclosporine, mycophenolate mofetil, sirolimus and everolimus may have toxic pulmonary effects, particularly interstitial alterations. The aim of the present study is to explore the presence of subclinical interstitial lung abnormalities in stable renal transplant recipients taking the different immunosuppressive drugs used as maintenance therapy for renal transplantation.

Description

Prospective, cross-sectional study examining the high-resolution CT scans obtained in 63 stable renal transplant recipients taking immunosuppressive treatment for at least 24 months. The findings in patients taking the newer immunosuppressive drugs (mycophenolic acid, sirolimus and everolimus) are compared with those of the patients treated in the traditional way (cyclosporine, tacrolimus, azathioprine). All patients undergo high-resolution CT scanning.

Eligibility criteria: recipients of kidney or kidney-pancreas transplant, on immunosuppressive therapy for at least 24 months, with stable renal function and absence of any overt lung disease or lung alterations induced by other drugs, systemic diseases or occupational exposure to fibrogenic agents.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Renal Transplantation

Intervention

High-resolution CT scanning

Location

Department of Clinical Medicine Nephrology and Health Science, Parma University Hospital
Parma
Italy
43100

Status

Active, not recruiting

Source

University of Parma

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:10:51-0400

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Medical and Biotech [MESH] Definitions

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Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.

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