Advertisement

Topics

Zurich Disability Prevention Trial

2014-08-27 03:17:50 | BioPortfolio

Summary

This project was designed to optimizing vitamin D status in prefrail seniors age 70+ living at home and prevent their functional decline. We test 3 arms of monthly vitamin D supplementation. Intermittent dosing will improve adherence and simplify vitamin D supplementation.

Description

We propose a double-blind, randomized controlled trial to test the effectiveness of a

1. Active I (n=70): monthly high-dose vitamin D3 supplement dose (60'000 IU/month, equivalent to 2000 IU daily),

2. Active II (n=70): or a monthly standard vitamin D3 supplement dose combined with 25(OH)D (24'000 IU/month, equivalent to 800 IU daily PLUS 300 mcg 25(OH)D, equivalent to 10 mcg per day)

3. Control (n=70): compared to a standard vitamin D3 supplement dose (24'000 IU/month, equivalent to 800 IU daily)

All individuals will be advised to consume calcium from natural food sources in a daily dose of 600-800 mgs a day, including milk products. Maximal intake of supplemental calcium is restricted to 250 mg per day.

Study Design

Allocation: Randomized, Control: Dose Comparison, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Conditions

Community-dwelling Seniors

Intervention

Hidroferol® (ES), ViDe3 (CH), ViDe3 (CH)

Location

Prof. H.A. Bischoff-Ferrari, MD, DrPH; Centre on Aging and Mobility
Zurich, Waid Hospital, Centre on Aging and Mobility
Switzerland
8091

Status

Recruiting

Source

University of Zurich

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:50-0400

Clinical Trials [324 Associated Clinical Trials listed on BioPortfolio]

Use of COLD-fX to Prevent Respiratory Infections in Community Dwelling Seniors

Seniors are a population vulnerable to respiratory infections. It is hypothesized that regular use of COLD-fX following an influenza vaccination would potentially augment immune response ...

Telemonitoring and Protocolized Case Management for Hypertensive Community Dwelling Seniors With Diabetes

Diabetes affects over 20% of Canadians over the age of 65y. Seniors with diabetes are at high risk for cardiovascular disease and death. Most of this risk is mediated through high blood pr...

Effect of Involving Community Dwelling Older People Receiving Meals-on-wheels in Activities in Relation to Meals

The clinical study's hypothesis is that community dwelling older people receiving meals-on-wheels can have an improvement in health-related quality of life and muscle strength, being invol...

The Relationship Between Atrial Fibrillation and Frailty in Community-Dwelling Elderly

Atrial fibrillation (AF) is the most common arrhythmias in clinical practice. Research investigating hospitalized patients have indicated there are deleterious effects of AF on patients be...

An Intervention to Preserve Functional Status and Independence Among Community Dwelling Elderly

This is a study aimed at identifying Olmsted County senior citizens who are at risk for vulnerability. Those elders who screen "affirmatively" for vulnerability will be offered participat...

PubMed Articles [1059 Associated PubMed Articles listed on BioPortfolio]

Does place matter? A multilevel analysis of victimization and satisfaction with personal safety of seniors in Canada.

Studies on the victimization and abuse of seniors in Canada have largely ignored the influence of place-based variations in social bonds and socioeconomic characteristics. Using the 2014 General Socia...

Characteristics and Patterns of Marijuana Use in Community-Dwelling Older Adults.

To understand patterns of marijuana use in community-dwelling older adults in Colorado.

Walking Aid Use in Canada: Prevalence and Demographic Characteristics Among Community-Dwelling Users.

Mobility limitations represent the third most prevalent cause of disability, affecting more than 1.9 million community-dwelling Canadians. Walking aids are often prescribed to reduce the impacts of mo...

Depression in Community-Dwelling Elderly Patients With Heart Failure.

The present cross-sectional study discussed the relationship between comorbid depression, demographic characteristics, clinical characteristics, and dietary self-efficacy among Taiwanese community-dwe...

Organizing seniors to protect the health safety net: the way forward.

Over the past century, the organized voice of seniors has been critical in building the U.S. health safety net. Since the 2016 election, that safety net, particularly the Medicaid program, is in jeopa...

Medical and Biotech [MESH] Definitions

The collective designation of three organizations with common membership: the European Economic Community (Common Market), the European Coal and Steel Community, and the European Atomic Energy Community (Euratom). It was known as the European Community until 1994. It is primarily an economic union with the principal objectives of free movement of goods, capital, and labor. Professional services, social, medical and paramedical, are subsumed under labor. The constituent countries are Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, and the United Kingdom. (The World Almanac and Book of Facts 1997, p842)

Non-residential facilities that are designed to provide care and companionship for seniors who need assistance or supervision during the day.

Family of small, surface-dwelling fish that inhabit fresh and brackish waters, and coastal marine areas.

A soil-dwelling actinomycete with a complex lifecycle involving mycelial growth and spore formation. It is involved in the production of a number of medically important ANTIBIOTICS.

Community or individual involvement in the decision-making process.

More From BioPortfolio on "Zurich Disability Prevention Trial"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Food
Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...

Alzheimer's Disease
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase  'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...


Searches Linking to this Trial