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Radiosurgery and Avastin for Recurrent Malignant Gliomas

2014-08-27 03:17:50 | BioPortfolio

Summary

The purpose of this study is to assess the central nervous system (CNS) toxicity in patients with recurrent malignant gliomas treated with concurrent Avastin and stereotactic radiosurgery (SRS).

Description

In this pilot study, 15 human subjects with recurrent, unifocal malignant gliomas up to 5-cm in maximum dimension no longer responding to conventional chemotherapy but able to tolerate further chemotherapy will be enrolled. The primary endpoint of this study will be the proportion of patients who experience CNS toxicity, with secondary endpoints progression-free survival, overall survival, steroid dosage, development of radionecrosis, quality of life, objective radiographic response and performance status.

Study Design

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Malignant Glioma

Intervention

Radiosurgery, Bevacizumab

Location

Duke University Medical Center, Radiation Oncology
Durham
North Carolina
United States
27710

Status

Enrolling by invitation

Source

Duke University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:50-0400

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