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RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about how docetaxel is used by the body.
PURPOSE: This research study is looking at DNA in tissue samples from Caucasian and African-American cancer patients who received docetaxel on clinical trial CLB-9871.
- To determine the genotype of ABCC2 and SLC01B3 (and other genes potentially relevant in the pharmacokinetics and pharmacodynamics of docetaxel in the future) in Caucasian and African-American cancer patients enrolled on clinical trial CLB-9871.
- Explore the relationships between these genotypes and the pharmacokinetic parameters (e.g., AUC, Vdss) of docetaxel.
OUTLINE: An aliquot from each DNA sample collected on clinical trial CLB-9871 is examined for ABCC2 and SLC01B3 genotyping using TaqMan analysis. The genotypes/haplotypes for the candidate genes will be correlated with the pharmacokinetic parameters of docetaxel and docetaxel-related toxicity.
Other genes related to the pharmacokinetics and side effects of docetaxel may be considered for future genotyping. In some cases, panels of drug response SNPs on high-density arrays may be genotyped.
docetaxel, DNA analysis, polymorphism analysis, laboratory biomarker analysis, pharmacological study
Active, not recruiting
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:17:55-0400
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