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Primary Operation in SYnchronous meTastasized InVasivE Breast Cancer

2014-08-27 03:17:55 | BioPortfolio

Summary

Primary Operation in synchronous metastasized invasive breast cancer to evaluate the use of local therapy

Description

This study is a prospective, randomized, multicentre, study concerning the influence of local treatment on the patients with synchronous metastasized breast cancer. Patients will be stratified at inclusion according to the centre, the menopausal status (pre-menopausal, post-menopausal), the hormone-receptor status (ER-/PR-/not determinable; any PR and/or Er+), the HER-2 status (positive vs. negative/not determinable), the grading (G1/G2/not determinable vs. G3), location of metastases (visceral ± vs bone only), organs with metastases (single organ vs multiple organs) and use of first line chemotherapy (anthracycline ± vs. taxane vs others). Thereafter patients will be randomly assigned to receive either local therapy of the breast (lumpectomy or mastectomy + axillary surgery /± radiotherapy) versus no local therapy. Systemic therapy will be administered at the centers policy.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Conditions

Synchronous Metastasized Breast Cancer

Intervention

Surgery, Surgery on Demand

Location

Medical University of Vienna-General Hospital Vienna
Vienna
Austria
1090

Status

Not yet recruiting

Source

Austrian Breast & Colorectal Cancer Study Group

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:55-0400

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