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Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) Over Temporoparietal Cortex on the Quality of Life of Refractory Schizophrenic Patients With Auditory Hallucinations

2014-08-27 03:17:56 | BioPortfolio

Summary

The primary outcome of this study is to evaluate the effects of low frequency repetitive Transcranial Magnetic Stimulation applied over the left temporoparietal cortex of refractory schizophrenic patients with auditory hallucinations on their quality of life and functionality.

The secondary outcome is to evaluate the effects of the same rTMS protocol on auditory hallucinations and general psychopathology.

Description

Seventeen patients with DSM-IV TR diagnosis of schizophrenia were randomized in two groups. First group received 20 sessions of 20 minutes each of low-frequency (1Hz) rTMS applied over the left temporoparietal cortex (LTPC).

Second group received sham (placebo) stimulation over the LTPC for the same period of time. All patients were considered as having refractory schizophrenia and in use of at least 400mg/day of clozapine and referred auditory hallucinations.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Conditions

Schizophrenia

Intervention

Active rTMS x sham (placebo) rTMS, sham rTMS, (1Hz) rTMS applied over the left temporoparietal cortex

Location

Hospital de Clinicas de Porto Alegre
Porto Alegre
RS
Brazil
90035-903

Status

Active, not recruiting

Source

Hospital de Clinicas de Porto Alegre

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:56-0400

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