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While sunitinib can be very helpful to treat kidney cancer, these medications can also cause side effects, including heart damage. Studies performed in the past did not look at heart function in detail, so the investigators do not know what happens to the heart when people start sunitinib treatment. The aim of the study is to prospectively study acute effects of sunitinib on heart function, overall fitness and blood markers of heart disease.
Participants will undergo cardiac MRI, maximal exercise testing(VO2 peak), blood and urine samples before and after 2 treatments of sunitinib. An extra blood sample will be collected the 2nd week of the first treatment to check blood levels of sunitinib. We will also examine the routine CT scans to study body composition.
Observational Model: Cohort, Time Perspective: Prospective
Renal Cell Carcinoma
University of Alberta/ Cross Cancer Institute
Not yet recruiting
Alberta Health Services
Published on BioPortfolio: 2014-08-27T03:17:57-0400
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