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A Prospective Study of Acute Cardiovascular Effects of First-line Sunitinib in Metastatic Renal Cell Carcinoma Patients (SUnitinib Prospective CardiovasculaR Effect)

2014-08-27 03:17:57 | BioPortfolio

Summary

While sunitinib can be very helpful to treat kidney cancer, these medications can also cause side effects, including heart damage. Studies performed in the past did not look at heart function in detail, so the investigators do not know what happens to the heart when people start sunitinib treatment. The aim of the study is to prospectively study acute effects of sunitinib on heart function, overall fitness and blood markers of heart disease.

Description

Participants will undergo cardiac MRI, maximal exercise testing(VO2 peak), blood and urine samples before and after 2 treatments of sunitinib. An extra blood sample will be collected the 2nd week of the first treatment to check blood levels of sunitinib. We will also examine the routine CT scans to study body composition.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Renal Cell Carcinoma

Location

University of Alberta/ Cross Cancer Institute
Edmonton
Alberta
Canada

Status

Not yet recruiting

Source

Alberta Health Services

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:17:57-0400

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